Scopus
YÖKSİS Eşleşti
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
World Journal of Men S Health · Ekim 2023
YÖKSİS Kayıtları
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
World Journal of Mens Health · 2023 SCI-Expanded
DOÇENT MURAT GÜL →
Makale Bilgileri
DergiWorld Journal of Men S Health
Yayın TarihiEkim 2023
Cilt / Sayfa41 · 809-847
Scopus ID2-s2.0-85163745039
Özet
Purpose: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method Results: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated. Conclusions: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians.
Yazarlar (100)
1
Ala'a Farkouh
ORCID: 0000-0002-0362-9109
2
Ashok Agarwal
ORCID: 0000-0003-0585-1026
3
Taha Hamoda
ORCID: 0000-0002-8070-4088
4
Parviz Kavoussi
ORCID: 0000-0001-7390-5837
5
Ramadan Saleh
ORCID: 0000-0003-0503-3533
6
Armand Zini
ORCID: 0000-0002-2194-5578
7
Mohamed Arafa
ORCID: 0000-0003-0107-8857
8
Ahmed M. Harraz
ORCID: 0000-0002-8902-517X
9
Murat Gul
ORCID: 0000-0002-6657-6227
10
Vilvapathy Senguttuvan Karthikeyan
ORCID: 0000-0002-0244-476X
11
Damayanthi Durairajanayagam
ORCID: 0000-0001-9049-0215
12
Amarnath Rambhatla
ORCID: 0000-0002-1383-6670
13
Florence Boitrelle
ORCID: 0000-0002-5322-0141
14
Eric Chung
ORCID: 0000-0003-3373-3668
15
Ponco Birowo
ORCID: 0000-0003-2934-6753
16
Tuncay Toprak
ORCID: 0000-0003-1348-5273
17
Ramy Abou Ghayda
ORCID: 0000-0002-5170-3983
18
Rossella Cannarella
ORCID: 0000-0003-4599-8487
19
Nguyen Ho Vinh Phuoc
ORCID: 0000-0002-4348-6034
20
Fotios Dimitriadis
ORCID: 0000-0003-1198-9144
21
Giorgio Ivan Russo
ORCID: 0000-0003-4687-7353
22
Ioannis Sokolakis
ORCID: 0000-0002-1938-8004
23
Taymour Mostafa
ORCID: 0000-0003-3627-0662
24
Konstantinos Makarounis
ORCID: 0000-0002-3971-8330
25
Imad Ziouziou
ORCID: 0000-0002-9844-6080
26
Shinnosuke Kuroda
ORCID: 0000-0001-8890-0297
27
Marion Bendayan
ORCID: 0000-0003-1633-7735
28
Raneen Sawaid Kaiyal
ORCID: 0000-0002-3111-3978
29
Andrian Japari
ORCID: 0000-0003-4733-6313
30
Mara Simopoulou
ORCID: 0000-0002-1000-9100
31
Lucia Rocco
ORCID: 0000-0001-6250-4798
32
Nicolas Garrido
ORCID: 0000-0001-8271-5218
33
Nazim Gherabi
ORCID: 0000-0001-7364-047X
34
Kadir Böcü
35
Oguzhan Kahraman
ORCID: 0000-0003-3691-8617
36
Tan V. Le
ORCID: 0000-0003-1766-7453
37
Christine Wyns
ORCID: 0000-0002-6581-5003
38
Kelton Tremellen
ORCID: 0000-0001-5575-6049
39
Selcuk Sarikaya
ORCID: 0000-0001-6426-1398
40
Sheena Lewis
ORCID: 0000-0001-5665-1572
41
Donald P. Evenson
ORCID: 0000-0002-5361-8299
42
Edmund Y. Ko
ORCID: 0000-0002-7465-3616
43
Aldo E. Calogero
ORCID: 0000-0001-6950-335X
44
Fahmi Bahar
ORCID: 0000-0002-7027-9436
45
Marlon Martinez
ORCID: 0000-0002-1191-8154
46
Andrea Crafa
ORCID: 0000-0002-8311-9095
47
Quang Nguyen
ORCID: 0000-0002-1670-8885
48
Rafael F. Ambar
ORCID: 0000-0002-3496-2895
49
Giovanni Maria Colpi
ORCID: 0000-0003-1431-1777
50
Mustafa Emre Bakircioglu
ORCID: 0000-0003-2411-9703
51
Ralf Henkel
ORCID: 0000-0003-1128-2982
52
Hussein Kandil
ORCID: 0000-0002-5549-3274
53
Ege Can Şerefoǧlu
54
Abdullah Alarbid
ORCID: 0000-0003-4822-9587
55
Akira Tsujimura
ORCID: 0000-0002-3821-5184
56
Alireza Kheradmand
ORCID: 0000-0002-4978-6935
57
Christina Anagnostopoulou
ORCID: 0000-0003-0999-6484
58
Angelo Marino
ORCID: 0000-0002-3558-8153
59
Aram Adamyan
ORCID: 0000-0002-7213-7212
60
Birute Zilaitiene
ORCID: 0000-0002-4082-4843
61
Cevahir Ozer
ORCID: 0000-0002-7850-6912
62
Edoardo Pescatori
ORCID: 0000-0002-9326-5598
63
Paraskevi Vogiatzi
ORCID: 0000-0001-9971-1619
64
Gian Maria Busetto
ORCID: 0000-0002-7291-0316
65
Giancarlo Balercia
ORCID: 0000-0003-1286-1521
66
Haitham Elbardisi
ORCID: 0000-0003-3902-7924
67
Hamed Akhavizadegan
ORCID: 0000-0002-5432-7311
68
Hesamoddin Sajadi
ORCID: 0000-0002-7198-0312
69
Hisanori Taniguchi
ORCID: 0000-0002-7404-0369
70
Hyun Jun Park
ORCID: 0000-0003-0566-9574
71
Israel Maldonado Rosas
ORCID: 0000-0003-2765-6176
72
Mohamed Al-Marhoon
ORCID: 0000-0002-8397-1560
73
Mohammad Ali Sadighi Gilani
ORCID: 0000-0001-6168-8599
74
Naif Alhathal
ORCID: 0000-0001-7516-3187
75
Germar M. Pinggera
ORCID: 0000-0001-6463-2494
76
Priyank Kothari
ORCID: 0000-0002-3940-952X
77
Nasser Mogharabian
ORCID: 0000-0001-8795-973X
78
Sava Micic
ORCID: 0000-0001-9037-3318
79
Sheryl Homa
ORCID: 0000-0001-5027-0066
80
Sara Darbandi
ORCID: 0000-0002-1868-6712
81
Tran Quang Tien Long
ORCID: 0000-0001-8905-3130
82
Wael Zohdy
ORCID: 0000-0001-9148-1425
83
Widi Atmoko
ORCID: 0000-0002-7793-7083
84
Marjan Sabbaghian
ORCID: 0000-0001-9439-268X
85
Wael Ibrahim
ORCID: 0000-0002-1651-8598
86
Ryan Patrick Smith
ORCID: 0000-0002-3880-9740
87
Christopher Chee Kong Ho
ORCID: 0000-0002-8757-6867
88
Jean De La Rosette
ORCID: 0000-0002-6308-1763
89
Ahmed I. El-Sakka
ORCID: 0000-0001-8671-5952
90
Mirko Preto
ORCID: 0000-0002-8144-6498
91
Catalina Zenoaga-Barbǎroşie
ORCID: 0000-0002-2854-9834
92
Saad Mohammed Abumelha
ORCID: 0000-0003-1885-3856
93
Aykut Baser
ORCID: 0000-0003-0457-512X
94
Kaan Aydos
ORCID: 0000-0001-7691-5459
95
Liliana Ramirez-Dominguez
ORCID: 0000-0002-8596-0654
96
Vijay Kumar
ORCID: 0000-0003-3768-8104
97
Teng Aik Ong
ORCID: 0000-0002-0207-8966
98
Tiago Cesar Mierzwa
ORCID: 0000-0001-7574-9540
99
Ricky Adriansjah
ORCID: 0000-0002-9733-3092
100
Saleem A. Banihani
ORCID: 0000-0002-6830-6247
Anahtar Kelimeler
Delphi method
Disease management
DNA fragmentation
Male infertility
Practice guideline
Survey
Kurumlar
Ajyal Hospital
Sohag Egypt
American Center for Reproductive Medicine
Moreland Hills United States
Andrology Group at Ideia Fertil Institute of Human Reproduction
Santo André Brazil
Ankara Üniversitesi
Ankara Turkey
Apollo Hospitals Group
Chennai India
Aristotle University of Thessaloniki
Thessaloniki Greece
Astghik Medical Center
Yerevan Armenia
Austin Fertility & Reproductive Medicine/Westlake IVF
Austin United States
Bandırma Onyedi Eylül University
Bandirma Turkey
Başkent Üniversitesi
Ankara Turkey
Binh Dan Hospital
Ho Chi Minh City Viet Nam
Biruni Üniversitesi
Istanbul Turkey
BYL Nair Charitable Hospital & TN Medical College
Mumbai India
Centre Hospitalier Intercommunal Poissy-St-Germain-en-Laye
Poissy France
Centro Universitário FMABC
Santo Andre Brazil
Cleveland Clinic Foundation
Cleveland United States
Cliniques Universitaires Saint-Luc
Brussels Belgium
Examen Lab Ltd.
Northern Ireland United Kingdom
Faculty of Medicine
Sohag Egypt
Faculty of Medicine
Cairo Egypt
Faculty of Medicine
Ismailia Egypt
Faculty of Medicine
Minya Egypt
Faculty of Medicine
Mansoura Egypt
Fakih IVF Fertility Center
Abu Dhabi United Arab Emirates
Farwania Hospital
Safat Kuwait
Fertility and Reproductive Health Diagnostic Center
Athens Greece
Fertility Care Center in Cairo
Cairo Egypt
Fertility Clinic
Curitiba Brazil
Flinders University
Adelaide Australia
Golestan Hospital (AJUMS)
Ahvaz Iran
Gynepro Medical
Bologna Italy
Hamad Medical Corporation
Doha Qatar
Hanoi Obstetrics and Gynecology Hospital
Hanoi Viet Nam
Henry Ford Hospital
Detroit United States
Hope Generation Foundation
Tehran Iran
Imperial College London
London United Kingdom
Instituto de Investigación Sanitaria La Fe
Valencia Spain
İstanbul Medipol Üniversitesi
Istanbul Turkey
IVF Laboratory
Mexico Mexico
Jordan University of Science and Technology
Irbid Jordan
Juntendo Urayasu Hospital
Urayasu Japan
Kansai Medical University
Hirakata Japan
Kaunas University of Medicine
Kaunas Lithuania
King Abdulaziz Medical City - Riyadh
Riyadh Saudi Arabia
King Abdulaziz University
Jeddah Saudi Arabia
King Faisal Specialist Hospital & Research Centre
Riyadh Saudi Arabia
Kurukshetra University
Kurukshetra India
Leto Maternity Hospital
Athens Greece
Locus Medicus S.A.
Athens Greece
Loma Linda University Health
Loma Linda United States
Medical School of Pusan National University
Yangsan South Korea
Medizinische Universitat Innsbruck
Innsbruck Austria
Next Fertility Procrea
Lugano Switzerland
Pham Ngoc Thach University of Medicine
Ho Chi Minh City Viet Nam
Pusan National University Hospital
Busan South Korea
Reproductive Medicine Unit
Palermo Italy
Royan Institute
Tehran Iran
Sabah Al Ahmad Urology Center
Kuwait City Kuwait
School of Medicine
Montreal Canada
School of Medicine
Athens Greece
SCSA Diagnostics
Brookings United States
Selçuk Üniversitesi
Selçuklu Turkey
SENSART Clinic
Istanbul Turkey
Shahroud University of Medical Sciences
Shahrood Iran
Siloam Sriwijaya Hospital
Palembang Indonesia
Silopi State Hospital
Sirnak Turkey
Sina Hospital
Tehran Iran
Sultan Qaboos University
Muscat Oman
Taylor's University Malaysia
Subang Jaya Malaysia
Telogorejo Hospital
Semarang Indonesia
The University of Queensland
Brisbane Australia
Università degli Studi della Campania Luigi Vanvitelli
Naples Italy
Università degli Studi di Catania
Catania Italy
Università degli Studi di Catania, Scuola di Medicina
Catania Italy
Università degli Studi di Foggia
Foggia Italy
Università degli Studi di Torino
Turin Italy
Università Politecnica delle Marche
Ancona Italy
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Central Jakarta Indonesia
Universitas Padjadjaran
Bandung Indonesia
Universitatea din Bucuresti
Bucharest Romania
Université d’Alger 1
Algiers Algeria
Université de Versailles Saint-Quentin-en-Yvelines
Versailles France
Université Ibn Zohr
Agadir Morocco
Universiti Malaya
Kuala Lumpur Malaysia
Universiti Teknologi MARA
Shah Alam Malaysia
University Hospitals Case Medical Center
Cleveland United States
University of Health Sciences
Istanbul Turkey
University of Kent
Canterbury United Kingdom
University of Santo Tomas Hospital
Manila Philippines
University of the Western Cape
Bellville South Africa
University of Virginia School of Medicine
Charlottesville United States
Uromedica Polyclinic
Belgrade Serbia
Viet Duc University Hospital
Hanoi Viet Nam
VNU-University of Medicine and Pharmacy
Hanoi Viet Nam
Weill Cornell Medicine-Qatar
Doha Qatar
Metrikler
17
Atıf
100
Yazar
6
Anahtar Kelime