Scopus
YÖKSİS Eşleşti
Short-Term Impact of Glycaemic Control and Intravitreal Ranibizumab Treatment on Serum Cytokine Levels and Diabetic Macular Edema in Patients with Unregulated Blood Glucose
Genel Tip Dergisi · Aralık 2022
YÖKSİS Kayıtları
Short-term impact of glycaemic control and intravitreal ranibizumab treatment on serum cytokine levels and diabetic macular edema in patients with unregulated blood glucose
Genel Tıp Dergisi · 2022 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ EMİNE TINKIR KAYITMAZBATIR →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiAralık 2022
Cilt / Sayfa32 · 774-780
Scopus ID2-s2.0-105009238945
Özet
Objective: To evaluate the short-term effect of glycaemic control and intravitreal ranibizumab treatment on diabetic macular edema (DME) and to assess the correlation between HbA1c and certain serum cytokines. Design: A prospective study of 43 participants with HbA1c levels exceeding 53 mmol/mol (7%) and with DME, as detected by spectral domain optical coherence tomography (SDOCT). Subjects: Participants were grouped according to their initial best corrected distance visual acuity (BCVA). Participants whose BCVA worse than +0.1 LogMAR (Group 1, n = 21) were treated with three monthly doses of intravitreal ranibizumab (0.5 mg) injections, and participants whose visual acuity equal to or better than +0.1 LogMAR (Group 2, n = 22) were followed without treatment. Methods: Serum cytokine levels, including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1(MCP-1), and vascular endothelial growth factor (VEGF) were analysed at the beginning and at the end of 3 months, using enzyme-linked immunosorbent assays (ELISA). Results: A significant decrease in macular thicknesses (except for one quadrant) was observed in Group 1. Changes in serum cytokine levels were not correlated with HbA1c decrease. Serum VEGF level was significantly increased in Group 1, despite the intravitreal treatment. Conclusion: Short-term glycaemic control alone had limited value in the treatment of DME. The therapeutic effect of intravitreal treatment on DME supports the role of the local cytokine milieu in the pathophysiology.
Yazarlar (7)
1
Emine Tınkır Kayıtmazbatır
ORCID: 0000-0002-8553-6992
2
Gulfidan Bitirgen
3
Gunhal Satirtav
ORCID: 0000-0003-4157-2876
4
Ibrahim Kilinc
5
Mustafa Kulaksızoğlu
ORCID: 0000-0001-9908-7449
6
Bulent Savut
ORCID: 0000-0003-3236-432X
7
Hürkan Kerimoğlu
Anahtar Kelimeler
Diabetes Mellitus
Glycaemic Control
Glycated Haemoglobin A1c
Macular Edema
Serum Cytokines
Type 2
Vascular Endothelial Growth Factor
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey