Scopus
YÖKSİS Eşleşti
The Importance of Expression of Keratin 17 (KRT17) and SPINK1 in Neoplastic (Invasive and Noninvasive) Lesions of the Bladder
Genel Tip Dergisi · Ağustos 2022
YÖKSİS Kayıtları
The importance of expression of Keratin 17 (KRT17) and SPINK1 in neoplastic (invasive and noninvasive) lesions of the bladder
Genel Tıp Dergisi · 2022 TR DİZİN
PROFESÖR NEVZAT SERDAR UĞRAŞ →
The Importance of Expression of Keratin 17 (KRT17) and SPINK1 in Neoplastic (Invasive and Noninvasive) Lesions of the Bladder
Genel Tıp Dergisi · 2022 TR DİZİN
PROFESÖR NEVZAT SERDAR UĞRAŞ →
The Importance of Expression of Keratin 17 (KRT17) and SPINK1 in Neoplastic (Invasive and Noninvasive) Lesions of the Bladder
genel tıp · 2022 TR DİZİN
DOÇENT İSMAİL HARMANKAYA →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiAğustos 2022
Cilt / Sayfa32 · 425-432
Scopus ID2-s2.0-105009242817
Özet
Objective: Diagnosis and grading of bladder cancers have a significant impact on treatment and prognosis. However, there are currently no very sensitive and specific immunohistochemical panels that can be used in the differential diagnosis of neoplastic lesions of the bladder and histomorphological findings are still the gold standard. We aimed to define the potential diagnostic importance of SPINK1, KRT17 and Laminin immunostaining in distinguishing neoplastic bladder lesions. Material and Methods: KRT17, SPINK1 and Laminin expressions were assayed in 141 tissue samples of non-neoplastic bladder mucosa (NBM) and neoplastic bladder lesions by immunohistochemistry. Results: KRT17 and SPINK1 are often expressed in tumoral tissues (86.2% and 68.7%, respectively). A statistically significant difference in KRT17 immunostaining was detected between the NBM and all seven neoplastic groups (p=0.03 to p<0.001). SPINK1 expression was significantly lower in NBM in comparison to neoplasms. Staining 2.5% or more of cells in tumor tissue with KRT17 distinguishes neoplastic lesions from nonneoplastic lesions with a sensitivity of 86.3% and a specificity of 100%. However, staining 12.5% or more of the cells in the tumor tissue with SPINK1 distinguishes neoplastic lesions from nonneoplastic lesions with a sensitivity of 62.6% and a specificity of 60%. Although both KRT17 and SPINK1 were stained in 60% of neoplasms, neither KRT17 nor SPINK1 staining was seen in 5.3% of neoplastic patients. Conclusion: Immunohistochemical panel consisting of KRT17, SPINK1 and Laminin can be used together with morphological findings for accurate diagnosis of bladder neoplasia.
Yazarlar (2)
1
Serdar Uğraş
2
İsmail Harmankaya
Anahtar Kelimeler
Bladder
Cancer
Immunohistochemistry
KRT17
SPINK1
TAT1
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey