Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tip Dergisi · Ağustos 2022
YÖKSİS Kayıtları
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tıp Dergisi · 2022 TR DİZİN
Doç. Dr. GÜLSÜM ALKAN →
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tıp Dergisi · 2022 TR DİZİN
Doç. Dr. GÜLSÜM ALKAN →
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tıp Dergisi · 2022 TR DİZİN
Prof. Dr. MELİKE EMİROĞLU →
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tıp Dergisi · 2022 TR DİZİN
Prof. Dr. MELİKE EMİROĞLU →
Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Genel Tıp Dergisi · 2022 TR DİZİN
Prof. Dr. AHMET SERT →
Makale Bilgileri
Dergi
Genel Tip Dergisi
Yayın TarihiAğustos 2022
Cilt / Sayfa32 · 415-424
Scopus ID2-s2.0-105009227301
Erişim🔓 Açık Erişim
Özet
Objective: Multisystem inflammatory syndrome in children (MIS-C), is a newly recognised life-threatening complication of coronavirus disease 2019 (COVID-19). Early determination of clinical severity of the disease is important for early decision of treatment regimens. The aim of this study is to investigate the severity classification value of a number of hematological parameters, inflammatory markers and biochemical tests in patients with MIS-C during the acute stage and after anti-inflammatory treatment. Material and Methods: In this retrospective case-controlled study, 64 children with MIS-C and 95 healthy age and gender matched children were included. Patients were divided into three clinical severity groups; mild, moderate, and severe. Results: Mean platelet volume (MPV), MPV to lymphocyte ratio (MPVLR), d-dimer, ferritin, interleukin 6 (IL-6) levels were significantly higher, while albumin levels were lower in the severe MIS-C group compared to all the other groups on admission. Neutrophil-to-lymphocyte ratio (NLR) and derived (d) NLR (d-NLR) levels were significantly higher in the moderate group compared to the mild group. In the pre-treatm ent period of MIS-C patients had higher MPV, platelet distribution width (PDW) values while they had lower white blood cell, lymphocyte, monocyte, haemoglobin, mean corpuscular volume (MCV), red cell distribution width (RDW), plateletcrit and platelet values compared to the post-treatment group. Lymphocyte, platelets, and haemoglobin levels were significantly higher in the control group compared to the pre-treatment group. Acute phase reactants, NLR, NMR, PLR, d-NLR, MPVLR and systemic inflammatory index were significantly higher in all MIS-C patients on admission compared to the control group. Conclusion: Specific routine laboratory test results may be useful in determining disease severity of MIS-C, possibly predicting the prognosis and early initiation of the appropriate treatment.
Yazarlar (4)
1
Gulsum Alkan
ORCID: 0000-0003-3384-769X
2
Ahmet Sert
ORCID: 0000-0002-1607-7569
3
Sadiye Kubra Tuter Oz
ORCID: 0000-0002-2473-5672
4
Melike Emiroglu
ORCID: 0000-0003-1307-0246
Anahtar Kelimeler
disease severity
hematological parameters
inflammatory markers
Multisystem inflammatory syndrome in children
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
6
Atıf
4
Yazar
4
Anahtar Kelime