Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SNP-43 polymorphism in CAPN10 gene is associated with Type 2 Diabetes risk in Konya region population
Genel Tip Dergisi · Eylül 2021
YÖKSİS Kayıtları
Konya bölgesi popülasyonunda CAPN10 genindeki SNP-43 polimorfizmi Tip 2 Diabetes riski ile ilişkilidir
Genel Tıp Dergisi · 2021 TR DİZİN
Doç. Dr. HÜLYA ÖZDEMİR →
Konya bölgesi popülasyonunda CAPN10 genindeki SNP-43 polimorfizmi Tip 2 Diabetes riski ile ilişkilidir
Genel Tıp Dergisi · 2021 TR DİZİN
Prof. Dr. HİLAL ARIKOĞLU →
Makale Bilgileri
Dergi
Genel Tip Dergisi
Yayın TarihiEylül 2021
Cilt / Sayfa31 · 290-294
Scopus ID2-s2.0-105009209658
Erişim🔓 Açık Erişim
Özet
Objective: Calpain-10 (CAPN10) is an atypical member of the Ca2+ dependent intracellular cysteine proteases family. It is expressed in many tissues and is essential for multiple cellular functions such as insulin secretion and activity. It is the first type 2 diabetes susceptibility gene identified. In our study, we aimed to analyze the relationship between CAPN10 gene polymorphisms (SNP-44,-43 and-137) and increased type 2 diabetes risk in a Turkish population. Material and Methods: 149 T2D patients and 48 healthy individuals were included in the study. Genotyping was performed using the PCR-SSCP technique, confirmed by DNA sequence analysis. The association between CAPN10 genotypes and T2D development and clinical features was statistically analyzed. Results: According to the results of the odds analysis, while no correlation was observed between SNP-44 and disease (OR: 1.417 CI: 0.452-4.436, P=0.740), a significant correlation was found between SNP-43 and disease (OR: 0.455 CI: 0.235-0.881, P=0.028). SNP-137 genotype distribution was detected as C/C in all patient and control individuals. No correlation was found between the scanned SNPs and clinical parameters (P>0.05). Conclusion: According to our results; SNP-43 in the CAPN10 gene is a risk factor for the development of T2D in the Turkish population.
Yazarlar (5)
1
Hülya Uçaryilmaz
2
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
3
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
4
Ahmet Bülent Turhan
ORCID: 0000-0002-5972-0147
5
Mustafa Sait Gonen
Anahtar Kelimeler
Calpain-10
polymorphism
Type 2 Diabetes
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey