Scopus
YÖKSİS Eşleşti
Evaluation of the Frequency of Blood Ammonia Test Requests in Clinic of Pediatrics Before and After the Establishment of the Department of Pediatric Metabolism
Genel Tip Dergisi · Ağustos 2024
YÖKSİS Kayıtları
Evaluation of the Frequency of Blood Ammonia Test Requests in Clinic of Pediatrics Before and After the Establishment of the Department of Pediatric Metabolism
Genel Tıp Dergisi · 2024 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ BANU KADIOĞLU YILMAZ →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiAğustos 2024
Cilt / Sayfa34 · 574-580
Scopus ID2-s2.0-105009330053
Özet
Background/Aims: Hyperammonemia causes severe mortality and morbidity when left unnoticed. We aimed to compare the number of ammonia test requests before and after establishing the Department of Pediatric Metabolism (DPM) in a clinic of pediatrics. Methods: The study was conducted retrospectively between 15/11/2022-16/11/2023. Study data were evaluated before (pre-group) and after (post-group) the establishment of DPM. Results: Two hundred eighty-five admissions were assessed in the study. There were 99 admissions in the pre-group and 186 in the post-group. There were 17 admissions for different reasons in the pre-group and 29 in the post-group. The most common reasons for admission were elevated transaminases, seizures, vomiting and metabolic acidosis. Definitive diagnosis was made in 16 (17.6%) patients admitted in the pre-group and 39 (23.8%) in the post-group. The most common diagnoses were genetic syndromes, mitochondrial diseases and organic acidemias. Twenty-one patients were diagnosed with inherited metabolic diseases (IMDs). Mitochondrial diseases were the most commonly diagnosed IMD (8(38%)). From the 15 pediatric subunits, ammonia test was requested from 8 in the pre-group and 13 in the post-group. In the pre-group, the pediatric subunit where ammonia was requested the most was the Pediatric Neurology Polyclinic (n=25 (25.3%)). In the post-group, the subunit that required the highest number of ammonia tests was the DPM (68(23.9%)). In the ROC analysis conducted for the predictive power of the initial ammonia level in requesting a control ammonia test, the area under the curve is 0.927, and the p-value is 0.001. For the cut-off value of 60.3 µmol/l, the sensitivity was 90.9%, and the specificity was 88.6%. Conclusion: After DPM was established, there was an increase in ammonia test requests, in the diversity of reasons for requesting ammonia testing from admissions, and in IMD diagnosis. DPM had a positive effect on pediatricians’ awareness of hyperammonemia.
Yazarlar (15)
1
Banu Kadıoğlu Yılmaz
2
İbrahim Abo Aljoud Jawad Ajam
ORCID: 0009-0008-2246-5550
3
Fuada Rzayeva
ORCID: 0009-0009-1444-3324
4
Mehmet Eren Güzel
ORCID: 0009-0005-7427-6987
5
Aslı Selen Yayla
ORCID: 0009-0008-3504-8561
6
Zeynep Azra Tekin
ORCID: 0009-0007-5205-3090
7
Senanur Aydın
ORCID: 0009-0005-7087-1404
8
Sena Nur Akyol
ORCID: 0009-0000-5557-5571
9
Yavuz Emre Eğri
ORCID: 0009-0006-1455-425X
10
İlknur Sert
ORCID: 0009-0004-9122-4137
11
Songül Güllibahçe
ORCID: 0009-0006-1590-7504
12
Emine Çoban
ORCID: 0009-0003-4521-7721
13
Mustafa Eren Özlü
ORCID: 0009-0000-5896-9330
14
Emirhan Eldem
ORCID: 0009-0009-7736-5749
15
Beyza Nur Eviz
ORCID: 0009-0003-9012-6319
Anahtar Kelimeler
Ammonia
Hyperammonemia
Inherited metabolic diseases
Pediatrics
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey