Scopus
YÖKSİS Eşleşti
Trimethylamine N-oxide, A Gut Microbiota-dependent Metabolite in Chronic Hepatitis B
Genel Tip Dergisi · Aralık 2024
YÖKSİS Kayıtları
Trimethylamine N-oxide, a gut microbiota-dependent metabolite in Chronic Hepatitis B
Genel Tıp Dergisi · 2024 TR DİZİN
PROFESÖR HÜSAMETTİN VATANSEV →
Trimethylamine N-oxide, a gut microbiota-dependent metabolite in Chronic Hepatitis B
Genel Tıp Dergisi · 2024 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Makale Bilgileri
DergiGenel Tip Dergisi
Yayın TarihiAralık 2024
Cilt / Sayfa34 · 853-860
Scopus ID2-s2.0-105009819757
Özet
Background: Trimethylamine N-oxide (TMAO), a gut microbiota metabolite is produced in the liver from dietary precursors such as choline, betaine, and L-carnitine. TMAO has been linked to inflammatory processes and oxidative stress, both of which are critical factors in the progression of hepatitis. This article aims to examine the impact of TMAO on chronic hepatitis B (CHB). Materials and Methods: The study included 41 treatment-naïve CHB patients with HBV DNA levels above 2000 IU/mL, as well as 46 age and gender-matched controls. Serum TMAO levels were measured using Liquid Chromatography-Tandem Mass Spectrometry (LC/MS/MS). All statistical analysis was performed with R version 4.2.1. Results: Patients with CHB have a more significant increase in serum level of TMAO than healthy controls (1860 [IQR, 808 – 2720] vs. 552.5 [IQR, 252 – 876.5], p 0.001) and had predictive power for CHB with an area under the curve of 0.808. Conclusions: Our results indicate that there is a link between TMAO, a gut microbiota-dependent metabolite, and CHB disease. Since TMAO is synthesized mainly in the liver, its raised levels may be associated with liver-related diseases.
Yazarlar (8)
1
Esra Paydas Hataysal
ORCID: 0000-0002-3538-8135
2
M. K. Korez
ORCID: 0000-0001-9524-6115
3
Nuray Heydar KASAR
ORCID: 0000-0003-4043-8755
4
Turan ASLAN
ORCID: 0000-0001-8832-5528
5
Fatma ŞENGÜL BAĞ
ORCID: 0000-0002-7097-6266
6
Hifa Gülru ÇAĞLAR
ORCID: 0000-0002-8142-6817
7
Alev KURAL
ORCID: 0000-0003-1459-4316
8
Hüsamettin Vatansev
Anahtar Kelimeler
HBV
LC/MS/MS
Microbiota
TMAO
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul Turkey
Pendik 9th Family Health Center
Istanbul Turkey
Research Hospital
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey