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The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses

European Geriatric Medicine · Aralık 2024

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YÖKSİS Kayıtları
The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses
European Geriatric Medicine · 2024 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses
European Geriatric Medicine · 2024 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →

Makale Bilgileri

DergiEuropean Geriatric Medicine
Yayın TarihiAralık 2024
Cilt / Sayfa15 · 1937-1948
DOI10.1007/s41999-024-01114-7
Scopus ID2-s2.0-85210473117
Erişim🔓 Açık Erişim
Özet Aim: To investigate the relationship between delirium and tryptophan and its metabolites in critically ill older patients. Findings: The level of TRP was significantly (borderline) decreased among patients with delirium (p = 0.056). The KYN/TRP and QA/TRP ratios were statistically and significantly higher in patients with delirium than those without (p < 0.001 and p = 0.016, respectively). The best predictive values for detecting delirium were calculated as ≤14,100 ng/mL for TRP (AUC: 0.601, p = 0.052), >1.12 for KYN/TRP ratio (AUC: 0.704, p < 0.001), and > 0.75 for QA/TRP ratio (AUC: 0.627, p = 0.013). The QA/TRP ratio showed independent and borderline significant association with being delirium in multivariable regression analysis (Odds ratio: 2.007, p = 0.066). Message: This study demonstrated that tryptophan and its metabolites obtained within the first 24 h of ICU admission might have predictive value for determining high-risk older patients for delirium.

Yazarlar (6)

1
Korhan Kollu
ORCID: 0000-0002-0973-724X
2
Hüseyin Kurku
3
Ali Ünlü
ORCID: 0000-0002-9991-3939
4
Busra Ecer
5
Ibrahim Guney
6
Muhammet Cemal Kızılarslanoğlu

Anahtar Kelimeler

Delirium Intensive care unit Kynurenine pathway Older patient Tryptophan

Kurumlar

Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
University of Health Sciences Türkiye
Karatay, Konya Turkey

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