Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Isotretinoin-Induced Sacroiliitis
Journal of Clinical Rheumatology · Aralık 2025
YÖKSİS Kayıtları
Isotretinoin-Induced Sacroiliitis: New Clinical Insights and Magnetic Resonance Imaging-Based Outcomes in a Real-Life Clinical Setting.
JCR: Journal of Clinical Rheumatology · 2025 SCI-Expanded
Dr. Öğr. Üyesi EZGİ AKYILDIZ TEZCAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Neuropathic Pain Component in Axial Spondyloarthritis and the Influence on Disease Burden
2018 ISSN: 1076-1608 SCI-Expanded
Doç. Dr. KEMAL EROL →
Diagnostic Performance of Lower Extremity Venous Wall Thickness and Laboratory Findings in the Diagnosis of the Behçet Disease
2022 ISSN: 1076-1608 SCI-Expanded Q3
Doç. Dr. HALİL ÖZER →
Diagnostic Performance of Lower Extremity Venous Wall Thickness and Laboratory Findings in the Diagnosis of the Behçet Disease
2022 ISSN: 1076-1608 SCI-Expanded Q2
Prof. Dr. MEHMET SEDAT DURMAZ →
Isotretinoin-Induced Sacroiliitis: New Clinical Insights and Magnetic Resonance Imaging-Based Outcomes in a Real-Life Clinical Setting.
2025 ISSN: 1076-1608 SCI-Expanded Q3
Dr. Öğr. Üyesi EZGİ AKYILDIZ TEZCAN →
Makale Bilgileri
ISSN10761608
Yayın TarihiAralık 2025
Cilt / Sayfa31 · e169-e174
Scopus ID2-s2.0-105007332810
Özet
Background Isotretinoin, a frequently prescribed treatment for severe acne vulgaris, is associated with rare but clinically important musculoskeletal adverse effects, notably sacroiliitis. Although previous studies reported an association, comprehensive long-term data on clinical outcomes, imaging progression, and risk of evolution to axial spondyloarthritis (axSpA) remain limited. Basically, previous studies commonly excluded patients with spondyloarthritis-related risk factors such as chronic inflammatory back pain, but this limits the generalization. This study uniquely evaluated the clinical course and progression of isotretinoin-induced sacroiliitis using objective magnetic resonance imaging (MRI) without excluding patients presenting these risk factors. Methods In this historical cohort study, patients with MRI-confirmed sacroiliitis during isotretinoin treatment were assessed. Clinical data including spondyloarthritis-associated features were recorded. Follow-up MRI performed at least 6 months later assessed inflammation resolution. Patients were classified according to Assessment of SpondyloArthritis International Society axSpA criteria. Statistical analyses were descriptive. Results Among the 16 patients, 14 underwent follow-up MRI; of these, 2 (14.3%) demonstrated persistent inflammation. Additionally, 1 patient met the Assessment of SpondyloArthritis International Society axSpA criteria clinically without repeat imaging. Overall, 3 patients (18.8%) progressed to axSpA, all with chronic inflammatory back pain, and 1 patient also had psoriasis. Half of the patients initially presenting with inflammatory back pain (3/6) progressed to axSpA during follow-up. Conclusion Although most isotretinoin-induced sacroiliitis resolves spontaneously, approximately one-fifth of cases may progress to axSpA, especially in patients with inflammatory back pain or other spondyloarthritis features. Clinicians should closely monitor isotretinoin-treated patients developing new or worsening back pain. Longitudinal studies are warranted to establish risk factors and optimize screening strategies.
Yazarlar (2)
1
Kemal Erol
ORCID: 0000-0003-0673-3961
2
Ezgi Akyildiz Tezcan
ORCID: 0000-0002-4988-1270
Anahtar Kelimeler
acne vulgaris
axial spondyloarthritis
isotretinoin
musculoskeletal adverse effects
sacroiliitis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Clinical Rheumatology
Q2
SJR Skoru0,612
H-Index66
YayıncıLippincott Williams and Wilkins
ÜlkeUnited States
Medicine (miscellaneous) (Q2)
Rheumatology (Q3)
Metrikler
2
Atıf
2
Yazar
5
Anahtar Kelime