Scopus
YÖKSİS Eşleşti
Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat
Heliyon · Temmuz 2025
YÖKSİS Kayıtları
Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat
Heliyon · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiHeliyon
Yayın TarihiTemmuz 2025
Cilt / Sayfa11
Scopus ID2-s2.0-105008107877
Özet
Aim: In this study, we investigated how Jervine affected gastric tissue in rats following the development of indomethacin-induced ulcers. Methods: Jervine (JER) 200 mg/kg and JER 400 mg/kg were given orally to the experimental groups 12h after the fasten period. Five minutes later, 25 mg/kg of indomethacin was administered orally to all groups except the healthy and JER 400 mg/kg groups. The experiment was concluded 6 h after the indomethacin. Results: The administration of Jervine at both doses resulted in a significant reduction of the ulcerative area compared to the Indomethacin (INDO). Indomethacin + Jervine 200 mg/kg (INDO + JER + 200 mg/kg) and Indomethacin + Jervine 400 mg/kg (INDO + JER + 400 mg/kg) groups significantly reduced apoptotic cell density compared to INDO group. Biochemically, Jervin decreased the Lipid Peroxidation (MDA) level which increased as a result of indomethacin. Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) levels, which decreased as a result of indomethacin, were found to increase. Jervine significantly downregulates p53 gene expression compared to the INDO group. Conclusion: In this study, we demonstrated the therapeutic properties of Jervine on ulcers due to its anti-apoptotic and antioxidant regulatory effects.
Yazarlar (9)
1
Serdar Yigit
ORCID: 0000-0001-5631-2335
2
Tuba Aydin
3
Nilnur Eyerci
ORCID: 0000-0002-6293-3338
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Lale Duysak
ORCID: 0000-0001-7872-3880
6
Fatma Necmiye Kaci
7
Erdem Toktay
ORCID: 0000-0002-0715-2707
8
Arzu Gezer
ORCID: 0000-0002-1658-2098
9
Seyit Ali Bingol
ORCID: 0000-0001-6422-9582
Anahtar Kelimeler
Anti-inflammatory
Antioxidant
Jervine
Rat
Ulcer
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Atatürk Üniversitesi
Erzurum Turkey
Erzurum Teknik Üniversitesi
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Tip Fakültesi
Konya Turkey