Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
Molecular Biology Reports · Aralık 2025
YÖKSİS Kayıtları
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
Molecular Biology Reports · 2025 SCI-Expanded
Dr. Öğr. Üyesi MUHAMMED YAYLA →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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Glutathione S-transferase M1 and T1 genotypes and myocardial infarction
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In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
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NF‑ĸβ upregulates ADAMTS5 expression by direct binding after TNF‑α
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Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
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Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
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Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge
between circadian rhythm and glucose metabolism, in a Turkish
population
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
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2022 ISSN: 0301-4851 SCI-Expanded Q4
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Glutathione S transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 SCI
Prof. Dr. HASAN ACAR →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. BAHADIR ÖZTÜRK →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
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Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. ESMA MENEVŞE →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation of the effects of gabapentin on high glucose-induced neurotoxicity and genotoxicity in an in vitro model of diabetic neuropathy and in silico molecular docking analysis
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi BATUHAN BİLGİN →
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Makale Bilgileri
ISSN03014851
Yayın TarihiAralık 2025
Cilt / Sayfa52
Scopus ID2-s2.0-105003260022
Özet
Background: Cisplatin (CIS), a widely used chemotherapeutic agent, is known for its severe neurotoxic side effects. This study investigates the neuroprotective effects of gossypin (GOS), a bioflavonoid with antioxidant and anti-inflammatory properties, against CIS-induced neurotoxicity. Methods and results: In-vitro and in-vivo experiments were conducted.50 male Mus Musculus mice were divided into five groups (n:10). Gossypin was administered at varying doses to (in-vitro: 50, 75, 100 µM; in vivo: 5, 10, 20 mg/kg/day) evaluate its protective effects. Results showed gossypin significantly improved cell viability dose-dependently, normalized oxidative stress markers Superoxide dismutase (SOD) activity and glutathione (GSH) and malondialdehyde (MDA) levels, reduced pro-apoptotic and inflammatory genes (CASP-3, CASP-9, TNF-α, NF-kB, iNOS), and increased anti-apoptotic markers (BCL2/BAX ratio, nNOS). Histopathological analysis revealed gossypin mitigated CIS-induced brain tissue damage. Conclusions: Gossypin exhibited significant neuroprotective effects against CIS-induced neurotoxicity via antioxidant (TNF-α), anti-inflammatory (NF-kB), and anti-apoptotic (BCL2/BAX ratio, nNOS) mechanisms by regulating various key regulatory genes, suggesting that it may be a promising adjuvant therapy to protect against the neurotoxic side effects of cisplatin in cancer treatment.
Yazarlar (4)
1
Irfan Cinar
ORCID: 0000-0002-9826-2556
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Pinar Bayram
ORCID: 0000-0001-9924-7051
4
Damla Binnetoğlu
ORCID: 0000-0002-7041-7253
Anahtar Kelimeler
Apoptosis
Cisplatin
Inflammation
Natural products
Neurodegenerative
Oxidative stress
Kurumlar
Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Molecular Biology Reports
Q2
SJR Skoru0,743
H-Index103
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Genetics (Q2)
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Metrikler
1
Atıf
4
Yazar
6
Anahtar Kelime