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Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo

Molecular Biology Reports · Aralık 2025

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YÖKSİS Kayıtları
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
Molecular Biology Reports · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →

Makale Bilgileri

DergiMolecular Biology Reports
Yayın TarihiAralık 2025
Cilt / Sayfa52
DOI10.1007/s11033-025-10501-7
Scopus ID2-s2.0-105003260022
Özet Background: Cisplatin (CIS), a widely used chemotherapeutic agent, is known for its severe neurotoxic side effects. This study investigates the neuroprotective effects of gossypin (GOS), a bioflavonoid with antioxidant and anti-inflammatory properties, against CIS-induced neurotoxicity. Methods and results: In-vitro and in-vivo experiments were conducted.50 male Mus Musculus mice were divided into five groups (n:10). Gossypin was administered at varying doses to (in-vitro: 50, 75, 100 µM; in vivo: 5, 10, 20 mg/kg/day) evaluate its protective effects. Results showed gossypin significantly improved cell viability dose-dependently, normalized oxidative stress markers Superoxide dismutase (SOD) activity and glutathione (GSH) and malondialdehyde (MDA) levels, reduced pro-apoptotic and inflammatory genes (CASP-3, CASP-9, TNF-α, NF-kB, iNOS), and increased anti-apoptotic markers (BCL2/BAX ratio, nNOS). Histopathological analysis revealed gossypin mitigated CIS-induced brain tissue damage. Conclusions: Gossypin exhibited significant neuroprotective effects against CIS-induced neurotoxicity via antioxidant (TNF-α), anti-inflammatory (NF-kB), and anti-apoptotic (BCL2/BAX ratio, nNOS) mechanisms by regulating various key regulatory genes, suggesting that it may be a promising adjuvant therapy to protect against the neurotoxic side effects of cisplatin in cancer treatment.

Yazarlar (4)

1
Irfan Cinar
ORCID: 0000-0002-9826-2556
2
Muhammed Yayla
ORCID: 0000-0002-0659-3084
3
Pinar Bayram
ORCID: 0000-0001-9924-7051
4
Damla Binnetoğlu
ORCID: 0000-0002-7041-7253

Anahtar Kelimeler

Apoptosis Cisplatin Inflammation Natural products Neurodegenerative Oxidative stress

Kurumlar

Kafkas Üniversitesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Tip Fakültesi
Konya Turkey

Sistemimizdeki Yazarlar

MY
MUHAMMED YAYLA
DOKTOR ÖĞRETİM ÜYESİ

Hızlı Erişim

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