Scopus
SJR Q2
Preclinical ocular microvascular changes in juvenile dermatomyositis: A pilot optical coherence tomography angiography study
Microvascular Research · Eylül 2022
Makale Bilgileri
Dergi
Microvascular Research
ISSN00262862
Yayın TarihiEylül 2022
Cilt / Sayfa143
Scopus ID2-s2.0-85131038745
Özet
Objectives: To evaluate the macular and optic nerve head (ONH) vascular density, foveal avascular zone area, and outer retina and choriocapillaris flow in juvenile dermatomyositis (JDM) using optical coherence tomography angiography (OCTA). Methods: Ten eyes of 10 patients with JDM and 15 age and sex-matched healthy controls were investigated in this prospective, cross-sectional study. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA. Results: Vessel density (VD) of the parafovea (p = 0.036) and parafoveal subregions (p = 0.041 for superior hemifield, p = 0.031 for inferior hemifield, p = 0.012 for superior, p = 0.019 for nasal, p = 0.026 for inferior, and p = 0.048 for temporal) in DCP were significantly lower in the JDM group compared to healthy controls. A high inverse correlation between disease duration and these parameters was found except parafoveal superior VD in DCP. There was no significant difference between the groups in VD parameters of SCP and ONH, FAZ parameters, outer retina, and choriocapillaris flow area as well as thickness parameters. (p > 0.05 for all). Furthermore, ROC analysis revealed that all parafoveal DCP parameters showed good ability to differentiate JDM from healthy controls. Conclusions: We demonstrated a decreased vessel density in the deep parafoveal region in JDM. As a result, we hypothesized that OCTA could detect retinal microvascular changes in JDM patients who did not have clinical evidence of ocular involvement.
Yazarlar (5)
1
Büşra Yılmaz Tuğan
ORCID: 0000-0001-6660-1608
2
Hafize Emine Sönmez
ORCID: 0000-0002-9186-3068
3
Mesut Güngör
ORCID: 0000-0003-1594-0006
4
Nurşen Yüksel
5
Levent Karabaş
ORCID: 0000-0003-4271-4741
Anahtar Kelimeler
Deep capillary plexus
Juvenile dermatomyositis (JDM)
Optical coherence tomography angiography
Parafovea
Kurumlar
Kocaeli Üniversitesi
İzmit Turkey
Scimago Dergi (ISSN Eşleşmesi)
Microvascular Research
Q2
SJR Skoru0,772
H-Index105
YayıncıAcademic Press Inc.
ÜlkeUnited States
Biochemistry (Q2)
Cardiology and Cardiovascular Medicine (Q2)
Cell Biology (Q3)
Metrikler
6
Atıf
5
Yazar
4
Anahtar Kelime