Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in experimental Alzheimer’s disease model
Cellular and Molecular Biology · Ocak 2025
YÖKSİS Kayıtları
Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in
experimental Alzheimer’s disease model
Cellular and Molecular Biology · 2025 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in experimental Alzheimer's disease model
Cellular and Molecular Biology · 2025 Scopus
DOKTOR ÖĞRETİM ÜYESİ EMİNE TINKIR KAYITMAZBATIR →
Makale Bilgileri
DergiCellular and Molecular Biology
Yayın TarihiOcak 2025
Cilt / Sayfa71 · 117-123
Scopus ID2-s2.0-105003263637
Erişim🔓 Açık Erişim
Özet
This study investigates the effects of regular exercise on inflammation and mitochondrial biogenesis in the eye using a controlled experimental Alzheimer’s disease (AD) model. Twenty-four male Wistar rats were divided into four groups: control, Alzheimer, exercise, and Alzheimer with exercise. Molecular markers, including Nuclear Factor Kappa B (NF-κB), Fibronectin Type III Domain-Containing Protein 5 (FNDC5), Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC-1α), Sirtuin 1 (SIRT1) were analyzed through real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) Matrix Metalloproteinase 2 (MMP-2), and Interleukin-1 Beta (IL-1β) were analyzed enzyme-linked immunosorbent assay (ELISA) to evaluate exercise-induced changes in inflammation and mitochondrial function. NF-κB levels were significantly elevated in the Alzheimer group, reflecting neuroinflammation, while exercise partially mitigated these effects. Exercise increased FNDC5, PGC-1α, and SIRT1 levels, suggesting a role in promoting neuroprotection and mitochondrial biogenesis. However, MMP-2 and IL-1β effects were primarily observed at the gene expression level, without substantial changes in protein levels. The use of an Alzheimer-specific model reduced confounding factors, such as age-related pathologies, providing a clearer perspective on Alzheimer-associated ocular changes. These findings highlight the potential of exercise in modulating key molecular pathways involved in AD.
Yazarlar (5)
1
Süleyman Okudan
2
Tuğba Sezer
3
Emine Tinkir Kayitmazbatir
4
Muaz Belviranli
5
Nilsel Okudan
Anahtar Kelimeler
Alzheimer’s disease
Exercise
Mitochondrial biogenesis
Neuroinflammation
NF-κB
PGC-1α
SIRT1
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey