Scopus
Microwave-assisted synthesis of 1,3-benzothiazol-2(3 H)-one derivatives and analysis of their antinociceptive activity
Arzneimittel-Forschung/Drug Research · Aralık 2012
Makale Bilgileri
DergiArzneimittel-Forschung/Drug Research
Yayın TarihiAralık 2012
Cilt / Sayfa62 · 571-575
Scopus ID2-s2.0-84871822990
Özet
A rapid and efficient method was developed for synthesis of 6-acyl-1,3-benzothiazol-2(3H)-one derivatives under microwave irradiation (MWI) conditions. The reaction times were shortened compared to conventional heating. Additionally, we synthesized acetic acid and acetamide derivatives of 1,3-benzothiazol-2(3H)-one, 6-acyl-1,3-benzothiazol-2(3H)-one, 5-chloro-1,3-benzothiazol-2(3H)-one and 6-acyl-5-chloro-1,3-benzothiazol-2(3H)- one with the microwave-assisted method and analyzed their antinociceptive activity with the tail flick, tail clip, hot plate and writhing tests. Among the synthesized compounds, 3-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-1,3- benzothiazol-2(3H)-one (6a), 5-chloro-3-{2-oxo-2-[4-(propan-2-yl) piperazin-1-yl]ethyl}-1,3-benzothiazol-2(3H)-one (7e) and 3-[2-(4- butylpiperazin-1-yl)-2-oxoethyl]-5-chloro-1,3-benzothiazol-2(3H)-one (8e) showed significant antinociceptive activity in the tail clip, tail flick, hot plate and writhing tests. Supporting Information available online at http://www.thieme-connect.de/ejournals/toc/amf.
Yazarlar (5)
1
T. Önkol
2
Y. Dündar
3
E. Yldrm
4
K. Erol
5
Mustafa Şahin
Anahtar Kelimeler
1,3-benzothiazol-2(3 H)-one
hot plate test
microwave-assisted synthesis
tail clip test
tail flick test
writhing test
Kurumlar
Eskişehir Osmangazi Üniversitesi
Eskisehir Turkey
Gazi Üniversitesi
Ankara Turkey
Metrikler
7
Atıf
5
Yazar
6
Anahtar Kelime