Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Using a combination of in vitro and in silico approaches to explore the biological potential of Arceuthobium oxycedri extracts: innovative insights from the lab to functional applications
European Food Research and Technology · Ağustos 2025
YÖKSİS Kayıtları
Using a combination of in vitro and in silico approaches to explore the biological potential of Arceuthobium oxycedri extracts: innovative insights from the lab to functional applications
European Food Research and Technology · 2025 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The effect of nitrogen fertilization on tocopherols in rapeseed genotypes
2008 ISSN: 1438-2377 SCI-Expanded
Dr. Öğr. Üyesi İRFAN ÖZER →
The effect of nitrogen fertilization on tocopherols in rapeseed genotypes
2008 ISSN: 1438-2377 SCI-Expanded 14 atıf
Dr. Öğr. Üyesi İRFAN ÖZER →
The effect of various types of poultry pre and post rigor meats on emulsification capacity water holding capacity and cooking loss
2005 ISSN: 1438-2377 SSCI 15 atıf
Prof. Dr. CEMALETTİN SARIÇOBAN →
The effect of irrigation and harvest time on bioactive properties of olive fruits issued from some olive varieties grown in Mediterranean region
2020 ISSN: 1438-2377 SCI
Doç. Dr. NURHAN USLU →
The effect of irrigation and harvest time on bioactive properties
of olive fruits issued from some olive varieties grown in Mediterranean
region
2020 ISSN: 1438-2377 SCI-Expanded
Prof. Dr. MEHMET MUSA ÖZCAN →
Volatile profile evolution and sensory evaluation of traditional skinbag Tulum cheeses manufactured in Karaman mountainous region of Turkey during ripening
2021 ISSN: 1438-2377 SCI-Expanded Q2
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Computer Vision Classification of Dry Beans (Phaseolus Vulgaris L.) Based on Deep Transfer Learning Techniques
2022 ISSN: 1438-2377 SCI-Expanded Q2
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The influence of decoction and infusion methods and times on antioxidant activity, caffeine content and phenolic compounds of coffee brews
2022 ISSN: 1438-2377 SCI-Expanded Q2
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A New Hybrid Model for Classification of Corn Using Morphological Properties
2023 ISSN: 1438-2377 SCI-Expanded Q2
Prof. Dr. ŞAKİR TAŞDEMİR →
The effect of nitrogen fertilization on tocopherols in rapeseed genotypes
2008 ISSN: 1438-2377 SCI-Expanded Q2
Dr. Öğr. Üyesi İRFAN ÖZER →
A review: benefit and bioactive properties of olive (Olea europaea L.) leaves
2016 ISSN: 1438-2377 SCI-Expanded
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Computer vision classification of dry beans (Phaseolus vulgaris L.) based on deep transfer learning techniques
2022 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. İLKER ALİ ÖZKAN →
Classification of Cicer arietinum varieties using MobileNetV2 and LSTM
2023 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. ADEM GÖLCÜK →
Benchmarking analysis of CNN models for bread wheat varieties
2023 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. ALİ YAŞAR →
Classification of Deep Image Features of Lentil Varieties with Machine Learning Techniques
2023 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. MURAT KÖKLÜ →
A New Hybrid Model for Classification of Corn Using Morphological Properties
2023 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. MURAT KÖKLÜ →
Detection of fish freshness using artificial intelligence methods
2023 ISSN: 1438-2377 SCI-Expanded Q2
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Segmentation of dry bean (Phaseolus vulgaris L.) leaf disease images with U-Net and classification using deep learning algorithms
2023 ISSN: 1438-2377 SCI-Expanded Q2
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Classification of Cicer arietinum varieties using MobileNetV2 and LSTM
2023 ISSN: 1438-2377 SCI-Expanded Q2
Doç. Dr. ALİ YAŞAR →
Makale Bilgileri
ISSN14382377
Yayın TarihiAğustos 2025
Cilt / Sayfa251 · 2445-2468
Scopus ID2-s2.0-105006926481
Erişim🔓 Açık Erişim
Özet
In the present study, the antioxidant capacity, enzyme inhibitory activities, and chemical composition of various extracts from Arceuthobium oxycedri were assessed by LC-MS/MS. Extracts were further evaluated for their cytotoxicity by the resazurin reduction assay and for their antioxidant activity by qRT-PCR in liver carcinoma HepG2 cells. The LC-MS/MS indicated that in both ethanolic and ethanol/water (70%) extracts, there were highly identified phenolic compounds, and they exhibited greater antioxidant effects. These extracts exhibited potential inhibitory activities against acetylcholinesterase and butyrylcholinesterase with the values of 4.72 and 4.41 mg GALAE/g, respectively. The ethanol extract showed the highest α-glucosidase inhibitory activity, 2.19 mmol ACAE/g, probably due to its high content of proanthocyanidins and hydroxycinnamic acids. Furthermore, results demonstrate that some of the extracts significantly reduce the expression of the antioxidant gene HO-1, while γ-GCS was slightly increased. To further investigate the molecular mechanisms, network pharmacology approach was used to identify potential targets related to HO-1 and NRF2.The analysis revealed key proteins associated with oxidative stress and metabolic pathways. Subsequently, molecular docking was performed on these identified targets, along with standard enzymes such as AChE, BChE, α-amylase, αglucosidase, and tyrosinase. The best-performing protein-ligand interactions were then selected for molecular dynamics simulations. These findings enable us to infer that ethanol and ethanol/water (70%) extracts represent the most promising candidates based on their chemical composition for their medicinal importance, represented by their rich contents of phenolic and flavonoid compounds.
Yazarlar (8)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Shakel Ahmed
3
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
4
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
5
Zoltán Cziáky
6
József Jekő
7
Tina Kostka
8
Tuba Esatbeyoglu
Anahtar Kelimeler
Antioxidants
A. oxycedri
Chemical profiling
Enzyme inhibition
In silico
Network pharmacology
Oxidative stress
Kurumlar
Gottfried Wilhelm Leibniz Universität Hannover
Hannover Germany
Harran University, Faculty of Medicine
Sanliurfa Turkey
Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
Kaiserslautern Germany
Selçuk Üniversitesi
Selçuklu Turkey
University of Nyíregyháza
Nyíregyháza Hungary
Scimago Dergi (ISSN Eşleşmesi)
European Food Research and Technology
Q1
SJR Skoru0,692
H-Index136
YayıncıSpringer Science and Business Media Deutschland GmbH
ÜlkeGermany
Industrial and Manufacturing Engineering (Q1)
Biochemistry (Q2)
Biotechnology (Q2)
Chemistry (miscellaneous) (Q2)
Food Science (Q2)
Metrikler
3
Atıf
8
Yazar
7
Anahtar Kelime