Scopus
YÖKSİS Eşleşti
Comprehensive chemical profiling, bioactivity evaluation, and computational modelling of various extracts from cleome ornithopodioides L
Natural Product Research · Ocak 2025
YÖKSİS Kayıtları
Comprehensive chemical profiling, bioactivity evaluation, and computational modelling of various extracts from Cleome ornithopodioides L
Natural Product Research · 2025 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiNatural Product Research
Yayın TarihiOcak 2025
Scopus ID2-s2.0-105003464263
Özet
In this study, various extracts of Cleome ornithopodioides L.: n-hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, 70% ethanol, and water (infusion) were used to examine the chemical profiles and biological activities of the plant. The characterisation of the compounds was carried out by HPLC coupled to ion trap mass spectrometry. Antioxidant activity was evaluated through six assays. Additionally, the enzyme inhibition activities of the extracts were tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase. The extracts showed varying levels of bioactive compounds, with the water (infused) (38.95 mg GAE/g) and the 70% ethanol (38.75 mg GAE/g) extracts having the highest total phenolics. The extracts primarily contained flavonoid glycosides (quercetin glycosides). The 70% ethanol extract exhibited the highest antioxidant activity as indicated by four assays (DPPH: 68.21 mg TE/g; ABTS: 193.48 mg TE/g; CUPRAC: 143.68; FRAP: 123.86 mg TE/g). The ethanol extract also showed significant inhibition of BChE (15.69 mg GALAE/g). This highlights their potential for future research into applications in health and medicine, where they could offer valuable therapeutic benefits.
Yazarlar (8)
1
Nilufar
2
E. J. Llorent-Martínez
3
Abdullahi Ibrahim Uba
4
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
5
Claudio Ferrante
6
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
7
Nikolaos Tzortzakis
ORCID: 0000-0002-2719-6627
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Cleome ornithopodioides L
docking
enzyme inhibition
flavonoid glycosides
health-promoting agents
Kurumlar
Cyprus University of Technology
Limassol Cyprus
Harran Üniversitesi
Sanliurfa Turkey
İstanbul Arel Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
University of G. d'Annunzio Chieti and Pescara
Chieti Italy