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Exploring hidden natural resources for bioactive compounds: Focused chemical and biological studies on some Anthemis species

Food and Chemical Toxicology · Ağustos 2025

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YÖKSİS Kayıtları
Exploring hidden natural resources for bioactive compounds: Focused chemical and biological studies on some Anthemis species
Food and Chemical Toxicology · 2025 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
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Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI-Expanded
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In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
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Organochlorine pesticide residues in wheat from Konya region Turkey
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Mineral and heavy metal levels of some fruits grown at the roadsides
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Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SSCI 23 atıf
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Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L dill samples cultivated under organic and conventional agricultural conditions
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Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
2018 ISSN: 0278-6915 SCI
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Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 02786915 SCI
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Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI
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Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI-Expanded
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Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI-Expanded
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Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
2017 ISSN: 02786915 SCI-Expanded
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Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
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UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
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Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
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Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
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Makale Bilgileri

Dergi Food and Chemical Toxicology
ISSN02786915
Yayın TarihiAğustos 2025
Cilt / Sayfa202
DOI10.1016/j.fct.2025.115467
Scopus ID2-s2.0-105004234416
Özet The present study investigated the phytochemical composition and biological activities of extracts from the aerial parts of Anthemis austriaca, A. cretica subsp. albida, A. pauciloba, A. tinctoria and A. wiedemanniana. About 150 compounds belonging to hydroxybenzoic acids, hydroxycinnamic acids, phenylethanoid glycosides, acylquinic acids, acylhexaric acids, flavonoids and sesquiterpene lactones were identified. A. tinctoria also displayed significant antiradical activity, obtained from its MeOH and 70 % MeOH extracts. EtOAc and MeOH extracts of A. pauciloba revealed the highest anti-acetylcholinesterase activity (3.51 and 3.50 mg GALAE/g; p > 0.05). Extracts had a higher affinity towards human carbonic anhydrase isoenzymes I (CAI) than CAII, and the best inhibition effect was exerted by EtOAc extract of A. wiedemanniana a (IC<inf>50</inf> 7.02 μg/mL). Network pharmacology analysis identified IL6 and TNFα as key targets of these plant-derived molecules, underscoring their multi-target potential. Anthemis extracts' efficacy in blunting LPS-induced IL6 and TNFα gene expression in isolated mouse colon has confirmed these predictions. Molecular docking studies further confirmed that these compounds interact with multiple transcription factors (TFs), suggesting broad pharmacological activity. These results indicated that the five Anthemis species could be a promising source of bioactive molecules.

Yazarlar (13)

1
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
2
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
3
Sakina Yagi
4
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
5
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
6
Gülçin
7
İsmail Yapıcı
8
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
9
Giustino Orlando
10
Luigi Menghini
ORCID: 0000-0002-7346-7395
11
Claudio Ferrante
12
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
13
Gokhan Zengin
ORCID: 0000-0001-6548-7823

Anahtar Kelimeler

Anthemis Carbonic anhydrase IL6 Network pharmacology Sesquiterpene lactone TNF

Kurumlar

Atatürk Üniversitesi
Erzurum Turkey
Harran University, Faculty of Medicine
Sanliurfa Turkey
Khartoum University
Khartoum Sudan
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Dergi sayfasına git

Metrikler

6
Atıf
13
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

EY
EVREN YILDIZTUGAY
Prof. Dr.

Hızlı Erişim

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