Scopus
YÖKSİS Eşleşti
Exploring hidden natural resources for bioactive compounds: Focused chemical and biological studies on some Anthemis species
Food and Chemical Toxicology · Ağustos 2025
YÖKSİS Kayıtları
Exploring hidden natural resources for bioactive compounds: Focused chemical and biological studies on some Anthemis species
Food and Chemical Toxicology · 2025 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiFood and Chemical Toxicology
Yayın TarihiAğustos 2025
Cilt / Sayfa202
Scopus ID2-s2.0-105004234416
Özet
The present study investigated the phytochemical composition and biological activities of extracts from the aerial parts of Anthemis austriaca, A. cretica subsp. albida, A. pauciloba, A. tinctoria and A. wiedemanniana. About 150 compounds belonging to hydroxybenzoic acids, hydroxycinnamic acids, phenylethanoid glycosides, acylquinic acids, acylhexaric acids, flavonoids and sesquiterpene lactones were identified. A. tinctoria also displayed significant antiradical activity, obtained from its MeOH and 70 % MeOH extracts. EtOAc and MeOH extracts of A. pauciloba revealed the highest anti-acetylcholinesterase activity (3.51 and 3.50 mg GALAE/g; p > 0.05). Extracts had a higher affinity towards human carbonic anhydrase isoenzymes I (CAI) than CAII, and the best inhibition effect was exerted by EtOAc extract of A. wiedemanniana a (IC<inf>50</inf> 7.02 μg/mL). Network pharmacology analysis identified IL6 and TNFα as key targets of these plant-derived molecules, underscoring their multi-target potential. Anthemis extracts' efficacy in blunting LPS-induced IL6 and TNFα gene expression in isolated mouse colon has confirmed these predictions. Molecular docking studies further confirmed that these compounds interact with multiple transcription factors (TFs), suggesting broad pharmacological activity. These results indicated that the five Anthemis species could be a promising source of bioactive molecules.
Yazarlar (13)
1
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
2
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
3
Sakina Yagi
4
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
5
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
6
Gülçin
7
İsmail Yapıcı
8
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
9
Giustino Orlando
10
Luigi Menghini
ORCID: 0000-0002-7346-7395
11
Claudio Ferrante
12
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
13
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Anthemis
Carbonic anhydrase
IL6
Network pharmacology
Sesquiterpene lactone
TNF
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Harran University, Faculty of Medicine
Sanliurfa Turkey
Khartoum University
Khartoum Sudan
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy