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Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats

Ankara Universitesi Veteriner Fakultesi Dergisi · Ocak 2023

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YÖKSİS Kayıtları
Hepatoprotective Effects of Nigella Sativa Oil against Acrylamide-induced Liver Injury in Rats
Ankara Üniversitesi Veteriner Fakültesi Dergisi · 2023 SCI-Expanded
PROFESÖR HASAN HÜSEYİN DÖNMEZ →

Makale Bilgileri

DergiAnkara Universitesi Veteriner Fakultesi Dergisi
Yayın TarihiOcak 2023
Cilt / Sayfa70 · 419-426
DOI10.33988/auvfd.1096306
Scopus ID2-s2.0-85173010811
Erişim🔓 Açık Erişim
Özet Acrylamide (AA) is a heat-induced carcinogen founds in some foods due to cooking or other thermal processes. This study was designed to investigate the possible protective efficacy of Nigella sativa essential oil against acrylamide-induced liver toxicity. Four groups of 32 male Wistar albino rats were formed. The control group was fed ad libitum. Acrylamide was administered to the rats in Group AA at a daily dose of 40 mg/kg by gavage. Nigella sativa essential oil was administered intraperitoneally at a dose of 10mg/kg to the rats in Group NS. In Group AA+NS, daily applications of acrylamide and Nigella sativa essential oil were applied simultaneously as mentioned above. The trial period lasted 15 days. While acrylamide statistically increased MDA levels in liver tissue (P<0.05), (146.13 %) and decreased GSH and SOD activity statistically (P<0.05), (55.28% and 40.46%). In addition, liver proinflammatory cytokine levels increased due to acrylamide administration (P<0.05), [TNF-α (78.17%), IL-6 (76.08%)], anti-inflammatory cytokine levels (P<0.05), [IL-10 (61.16%)] decreased. Co-administration of Nigella sativa essential oil with acrylamide significantly reduced oxidative stress and pro-inflammatory cytokine levels in liver tissues (P<0.05). In conclusion, our findings highlighted the potential therapeutic role of Nigella sativa essential oil in preventing acrylamide-induced hepatotoxicity.

Yazarlar (4)

1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
M. Özsan
3
Hasan Hüseyin Dönmez
4
Nurcan Dönmez

Anahtar Kelimeler

Acrylamide Cytokines Hepatotoxicity Nigella sativa Oxidative stress

Kurumlar

Bartin Üniversitesi
Bartin Turkey
Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

4
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

HD
HASAN HÜSEYİN DÖNMEZ
PROFESÖR

Hızlı Erişim

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