Scopus
YÖKSİS Eşleşti
Protective Effect of N-Acetylcysteine Against Aluminum-Induced Kidney Tissue Damage in Rats
Biological Trace Element Research · Nisan 2023
YÖKSİS Kayıtları
Protective Effect of N-Acetylcysteine Against Aluminum-Induced Kidney Tissue Damage in Rats
Biological Trace Element Research · 2023 SCI-Expanded
PROFESÖR MURAT BOYDAK →
Protective Effect of N-Acetylcysteine Against Aluminum-Induced Kidney Tissue Damage in Rats
BIOLOGICAL TRACE ELEMENT RESEARCH · 2023 SCI
PROFESÖR HASAN HÜSEYİN DÖNMEZ →
Protective effect of Nacetylcysteine against aluminum-induced kidney tissue damage in rats
Biological Trace Element Research · 2023 SCI-Expanded
PROFESÖR HASAN HÜSEYİN DÖNMEZ →
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiNisan 2023
Cilt / Sayfa201 · 1806-1815
Scopus ID2-s2.0-85129811174
Özet
Aluminum (AL) is an important nephrotoxic agent with a high daily exposure rate and property of accumulation in tissues. This study aimed to investigate the potential protective efficacy of N-acetylcysteine (NAC) against AL exposure-induced nephrotoxicity in rats. Twenty-eight rats were randomly divided into 4 groups as control, N-acetylcysteine group (NC), AL, and AL + NC, with an equal number of rats in each group (n = 7). No application was made to the control group. A total of 150 mg/kg/day NAC was administered to the NC group and 30 mg/kg/day AL was administered to the AL group intraperitoneally (i.p.). The AL + NC group received 30 mg/kg/day AL and 150 mg/kg/day NAC i.p. Biochemical parameters in blood serum and histopathological changes in kidney tissue, oxidative stress parameters, spexin (SPX), and apoptotic protein levels were examined after 15 days. Histopathological changes, biochemical parameters, oxidative stress parameters, and apoptotic protein levels were significantly irregular in the AL group compared to the control group. Moreover, SPX levels increased in the AL group. However, NAC treatment regulated AL exposure-related changes in the AL + NC group. NAC treatment may have a prophylactic effect against nephrotoxicity due to AL exposure. SPX may play a role in AL-induced nephrotoxicity.
Yazarlar (4)
1
Sercan Kaya
ORCID: 0000-0001-9014-2448
2
Tuba Yalçın
ORCID: 0000-0002-2359-9832
3
M. Boydak
4
Hasan Hüseyin Dönmez
Anahtar Kelimeler
Aluminum
N-acetylcysteine
Nephrotoxicity
Neuropeptide Q
Spexin
Kurumlar
Batman University
Batman Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
18
Atıf
4
Yazar
5
Anahtar Kelime