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Scopus 🔓 Açık Erişim YÖKSİS Eşleşti

Effect of hepatosteatosis on the virological response in Entecavir and Tenofovir therapies

Klimik Dergisi · Aralık 2019

YÖKSİS Kayıtları

Hepatosteatozun Entekavir ve Tenofovir Tedavilerinde Virolojik Yanıta Etkisi

KLİMİK DERGİSİ · 2019 Web of Science-Emerging SourcesCitation Index, TUBITAK ULAKBIM TR Index, EMBASE, Scopus,CINAHL, Gale/Cengage Learning, EBSCO, DOAJ, HINARI, ProQuest databases

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Effect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies

Klimik Dergisi/Klimik Journal · 2020 TR DİZİN

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Hepatosteatozun Entekavir ve Tenofovir Tedavilerinde Virolojik Yanıta Etkisi

KLİMİK DERGİSİ · 2019 Web of Science-Emerging SourcesCitation Index, TUBITAK ULAKBIM TR Index, EMBASE, Scopus,CINAHL, Gale/Cengage Learning, EBSCO, DOAJ, HINARI, ProQuest databases

PROFESÖR ONUR URAL →

Hepatosteatozun Entekavir ve Tenofovir Tedavilerinde Virolojik Yanıta Etkisi

Klimik Dergisi/Klimik Journal · 2020 Web of Science-Emerging Sources Citation Index,TÜBİTAK ULAKBİM TR Dizin, EMBASE, Scopus, CINAHL, Gale/Cengage Learning, EBSCO, DOAJ, HINARI ve ProQuest

PROFESÖR ONUR URAL →

Hepatosteatozun Entekavir ve Tenofovir Tedavilerinde Virolojik Yanıta Etkisi

KLİMİK Dergisi · 2019 TR DİZİN

PROFESÖR ONUR URAL →

Makale Bilgileri

DergiKlimik Dergisi

Yayın TarihiAralık 2019

Cilt / Sayfa32 · 265-274

DOI10.5152/kd.2019.73

Scopus ID2-s2.0-85077860443

Erişim🔓 Açık Erişim

Özet Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48th week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results.

Yazarlar (36)

Pınar Korkmaz

ORCID: 0000-0001-5035-5895

Neşe Demirtürk

ORCID: 0000-0002-6186-2494

Ayse Batirel

Necla Tülek

ORCID: 0000-0002-3952-4982

Müge Özgüler

ORCID: 0000-0002-2689-7931

Rezan Harman

ORCID: 0000-0003-4342-6741

Güle Çınar

ORCID: 0000-0002-7635-8848

Onur Toka

ORCID: 0000-0002-4025-4537

Gülşen Yörük

ORCID: 0000-0002-0357-5884

Çiğdem Ataman-Hatipoğlu

ORCID: 0000-0002-1104-8232

Figen Sarıgül

ORCID: 0000-0001-8646-2203

Fatma Sırmatel

ORCID: 0000-0003-0442-5981

Ayfer İmre

ORCID: 0000-0002-1885-8895

Duru Mıstanoğlu-özatağ

ORCID: 0000-0002-0005-192X

Faruk Karakeçili

ORCID: 0000-0002-7368-7187

Onur Ural

Şua Sümer

Nazlım Aktuğ Demir

Ayten Kadanali

Senol Çomoglu

Şengül Üçer

ORCID: 0000-0002-1764-3198

Neşe Saltoğlu

ORCID: 0000-0003-4239-9585

Özgür Günal

ORCID: 0000-0002-7744-4123

Hacer Deniz Özkaya

ORCID: 0000-0002-5212-9629

Ercan Yenilmez

ORCID: 0000-0002-1145-8856

Rıza Aytaç Çetinkaya

ORCID: 0000-0002-5676-9527

Esma Yüksel

ORCID: 0000-0003-0898-9573

İsmail Necati Hakyemez

ORCID: 0000-0001-6133-9604

Meliha Meriç-Koç

ORCID: 0000-0002-0563-6900

Günay Tuncer-Ertem

ORCID: 0000-0001-8760-0030

Zehra Beştepe-Dursun

ORCID: 0000-0002-6736-0380

Ilhami Celik

Emel Yılmaz

ORCID: 0000-0002-3894-1231

Güliz Evik

ORCID: 0000-0003-2125-3536

A. Kaya

Kaya Süer

ORCID: 0000-0002-2565-3425

Anahtar Kelimeler

Entecavir Fatty liver Tenofovir

Kurumlar

Afyonkarahisar Health Sciences University

Afyonkarahisar Turkey

Ankara Üniversitesi

Ankara Turkey

Bezmiâlem Vakıf Üniversitesi

Istanbul Turkey

Bolu Abant İzzet Baysal Üniversitesi

Bolu Turkey

Bursa Uludağ Üniversitesi

Bursa Turkey

Elazığ Fethi Tekin Şehir Hastanesi

Elazig Turkey

Erzincan Binali Yıldırım Üniversitesi

Erzincan Turkey

Hacettepe Üniversitesi

Ankara Turkey