Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
How Important are the Maternal Hepatitis B Viral Load and HbeAg Status in Neonatal Immunoprophylaxis Failure?
Cocuk Enfeksiyon Dergisi · Aralık 2024
YÖKSİS Kayıtları
How Important are the Maternal Hepatitis B Viral Load and HBeAg Status in Neonatal Immunoprophylaxis Failure?
Journal of Pediatric Infection · 2024 ESCI
DOÇENT MELİKE EMİROĞLU →
How Important are the Maternal Hepatitis B Viral Load and HbeAg Status in Neonatal Immunoprophylaxis Failure?
Journal of Pediatric Infection · 2024 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ MELTEM GÜMÜŞ →
How Important are the Maternal Hepatitis B Viral Load and HbeAg Status in Neonatal Immunoprophylaxis Failure?
Journal of Pediatric Infection · 2024 TR DİZİN
PROFESÖR HALİL HALDUN EMİROĞLU →
How Important are the Maternal Hepatitis B Viral Load and HbeAg Status in Neonatal Immunoprophylaxis Failure?
Journal of Pediatric Infection · 2024 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Makale Bilgileri
DergiCocuk Enfeksiyon Dergisi
Yayın TarihiAralık 2024
Cilt / Sayfa18 · e215-e220
Scopus ID2-s2.0-85213701817
Erişim🔓 Açık Erişim
Özet
Objective: The present study aimed to determine the significance of maternal hepatitis B viral load and HBeAg status in neonatal immunoprophylaxis failure. Material and Methods: The present study was designed as a retrospective case study (n= 52). Children who were followed up due to immunoprophylaxis failure and the development of chronic hepatitis B infection were included in the case group (n= 16). The control group (n= 36) included children with successful immunoprophylaxis. The viral load (high/low) and HBeAg status (positive/negative) of the mothers of both groups of the children were compared. Furthermore, possible factors that could lead to immunoprophylaxis failure (gestational age, birth weight, delivery method, premature membrane rupture, breastfeeding length) were also analyzed in both groups. Results: A moderate positive correlation (φ= 0.549, p< 0.001) was determined between the viral loads and a strong positive correlation (φ= 0.758, p< 0.001) was determined between HBeAg statuses. However, gestational age, birth weight, delivery methods, history of premature rupture of membranes, and breastfeeding duration were similar in both groups. Conclusion: Neonatal immunoprophylaxis failure risk was statistically higher if the mother is HBeAg positive and/or has a high viral load (≥2000 IU/mL).
Yazarlar (5)
1
Sekibe Isik Disci
2
Halil Haldun Emiroğlu
3
Melike Emiroglu
ORCID: 0000-0003-1307-0246
4
Meltem Gumus
5
M. K. Korez
ORCID: 0000-0001-9524-6115
Anahtar Kelimeler
HbeAg
Hepatitis B
neonatal immunoprophylaxis
viral load
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Seydisehir State Hospital
Konya Turkey