Scopus
Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors
Bioorganic and Medicinal Chemistry · Ekim 2014
Makale Bilgileri
DergiBioorganic and Medicinal Chemistry
Yayın TarihiEkim 2014
Cilt / Sayfa22 · 5141-5154
Scopus ID2-s2.0-84907541193
Özet
Hydroxylated 6H-benzo[c]chromen-6-one derivatives (i.e., urolithins) are the main bioavailable metabolites, and biomarkers of ellagitannins present in various nutrition. Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease. Therefore, within this research, a series of 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives has been designed, synthesized, and their biological activities were evaluated as potential acetylcholinesterase and butyrylcholinesterase inhibitors. The compounds synthesized exerted comparable activity in comparison to rivastigmine, galantamine, and donepezil both in in vitro and in vivo studies.
Yazarlar (7)
1
Hayrettin Ozan Gulcan
2
Serdar Ünlü
3
Ilker Esiringu
4
Tugba Ercetin
5
Yasemin Şahin
6
Demet Öz
7
Mustafa Şahin
Anahtar Kelimeler
6H-Benzo[c]chromen-6-ones
Acetylcholinesterase
Alzheimer's Disease
Butyrylcholinesterase
Passive avoidance test
Kurumlar
Eastern Mediterranean University
Famagusta Turkey
Nobel Drug Pharmaceutical RandD Center (Nobel-Ilac Ar-Ge Merkezi)
Turkey
Metrikler
42
Atıf
7
Yazar
5
Anahtar Kelime