Scopus
YÖKSİS Eşleşti
Neurotrophic factor levels and executive functions in children of parents with bipolar disorder: A case controlled study
Journal of Affective Disorders · Ağustos 2024
YÖKSİS Kayıtları
Neurotrophic factor levels and executive functions in children of parents with bipolar disorder: A case controlled study
Journal of Affective Disorders · 2024 SSCI
PROFESÖR SERHAT TÜRKOĞLU →
Makale Bilgileri
DergiJournal of Affective Disorders
Yayın TarihiAğustos 2024
Cilt / Sayfa359 · 327-332
Scopus ID2-s2.0-85194080840
Özet
Background: In the current study, it was aimed to evaluate neurotrophic factor levels and their relationship with executive functions in high-risk children and adolescents (high-risk group) whose parents were diagnosed with bipolar disorder (BD) but not affected by any psychiatric disease,and in order to determine possible vulnerability factors related to the disease. Methods: The study sample consisted of 32 high-risk group and 34 healthy controls. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version-Turkish Adaptation (KSADS-PL-T), Stroop Test, Serial Digit Learning Test (SDLT) and Cancellation Test to evaluate executive functions were administered to all participants by the clinician.Serum levels of neurotrophic factors were measured using commercial enzyme linked immunosorbent assay kits. Results: Serum BDNF, NT-3, NT-4 levels and SDLT scores were significantly lower in the high-risk group for BD compared to the healthy control group. A moderate negative correlation was found between BDNF levels and the Cancellation Test scores in the high-risk group. In addition to these results, the odds ratios of age, NT-4, SDLT scores for being in the risky group in terms of BD diagnosis were 1.26, 0.99 and 0.86 respectively. Limitations: This was a cross-sectional study. Causality between study results is therefore difficult to establish. The relatively small sample size of the study is another limitation. Conclusion: The results of the present study suggest that BDNF, NT-3, NT-4 may play a role in the physiopathology of BD and may be associated with impaired executive function areas such as attention and response inhibition in the high-risk group.
Yazarlar (7)
1
Özlem Çiçek Zekey
2
Halit Necmi Uçar
ORCID: 0000-0002-2706-7454
3
Fikret Akyürek
4
Gökçeçiçek Arıcı Sağlıyan
5
Fatih Hilmi Çetin
6
Serhat Türkoğlu
7
Kürşat Altınbaş
Anahtar Kelimeler
Bipolar offspring
Executive function
High-risk group
Neurotrophic factor
Kurumlar
Diamind Zihin Akademisi
Konya Turkey
Konya City Hospital
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Sivas Numune Hospital
Sivas Turkey
Special Clinic
Konya Turkey