Scopus
YÖKSİS DOI Eşleşti
SJR Q2
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · Ocak 2022
YÖKSİS Kayıtları
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
Prof. Dr. HASAN ACAR →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
DRUG AND CHEMICAL TOXICOLOGY · 2022 SCI-Expanded
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
DRUG AND CHEMICAL TOXICOLOGY · 2022 SCI-Expanded
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2022 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Assessment of Antimutagenic Action of Celtis glabrata Steven ex Planch Cannabaceae Extracts Against Base Pair Exchange and Frame Shift Mutations on Salmonella typhimurium TA98 and TA100 Strains by Ames Test
2016 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs
2012 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SCI-Expanded
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SSCI
Prof. Dr. MUSTAFA ONUR ALADAĞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q3
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. HASAN ACAR →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
2023 ISSN: 0148-0545 SCI-Expanded Q2
Doç. Dr. MEHMET BURAK ATEŞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. NADİRE ÜNVER DOĞAN →
The neuroprotective effect of 1,25-dyhydroxyvitamin D3 (calcitriol) and probiotics on the rotenone-induced neurotoxicity model in SH-SY5Y cells
2025 ISSN: 0148-0545 SCI-Expanded Q3
Dr. Öğr. Üyesi FATMA HAZAN DOĞAN →
Makale Bilgileri
ISSN01480545
Yayın TarihiOcak 2022
Cilt / Sayfa45 · 2739-2747
Scopus ID2-s2.0-85118445533
Özet
This study aimed to evaluate the effects of the glucocorticoid prednisolone, the mycophenolic acid prodrug, azathioprine, and the fungi fermentation end product, mycophenolate mofetile on the embryological development of rats. Nine day-old rat embryos were cultured in rat serum containing prednisolone at varying concentrations (5–30 µg/ml) for 48 h. The test groups were cultured separately in rat serum containing 0.3–10 µg/ml azathioprine and 1–10 µg/ml mycophenolate mofetile. Embryonic development parameter effects of both drugs in combination with prednisolone (20 µg/ml) were studied using morphological methods, with special attention given to the incidence of malformations. The genotoxic effects of agents evaluated with the TUNEL test revealed that prednisolone is not a cause of developmental toxicity. The maximum safe dose of prednisolone that could be used in combination with other immunosuppressive agents was determined to be 20 µg/ml. Azathioprine was found to be toxic and teratogenic for the rat embryos beginning at a dose of 1 µg/ml. Dose-dependent toxic and teratogenic effects of mycophenolate mofetile were detected at doses lower than normal clinical ones.
Yazarlar (5)
1
Zeliha Fazliogullari
ORCID: 0000-0002-5103-090X
2
Ahmet Kagan Karabulut
3
Nadire Unver Dogan
4
Ismihan Ilknur Uysal
5
Hasan Acar
Anahtar Kelimeler
Azathioprine
mycophenolate mofetile
prednisolone
TUNEL assay
whole embryo culture
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Drug and Chemical Toxicology
Q2
SJR Skoru0,538
H-Index57
YayıncıInforma Healthcare
ÜlkeUnited States
Medicine (miscellaneous) (Q2)
Public Health, Environmental and Occupational Health (Q2)
Chemical Health and Safety (Q3)
Health, Toxicology and Mutagenesis (Q3)
Pharmacology (Q3)
Toxicology (Q3)
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime