Scopus
YÖKSİS Eşleşti
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · Ocak 2022
YÖKSİS Kayıtları
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2022 SCI-Expanded
PROFESÖR ZELİHA FAZLIOĞULLARI →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
PROFESÖR HASAN ACAR →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
PROFESÖR AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
PROFESÖR NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
DRUG AND CHEMICAL TOXICOLOGY · 2022 SCI-Expanded
PROFESÖR AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
Drug and Chemical Toxicology · 2021 SCI-Expanded
PROFESÖR NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
DRUG AND CHEMICAL TOXICOLOGY · 2022 SCI-Expanded
PROFESÖR NADİRE ÜNVER DOĞAN →
Makale Bilgileri
DergiDrug and Chemical Toxicology
Yayın TarihiOcak 2022
Cilt / Sayfa45 · 2739-2747
Scopus ID2-s2.0-85118445533
Özet
This study aimed to evaluate the effects of the glucocorticoid prednisolone, the mycophenolic acid prodrug, azathioprine, and the fungi fermentation end product, mycophenolate mofetile on the embryological development of rats. Nine day-old rat embryos were cultured in rat serum containing prednisolone at varying concentrations (5–30 µg/ml) for 48 h. The test groups were cultured separately in rat serum containing 0.3–10 µg/ml azathioprine and 1–10 µg/ml mycophenolate mofetile. Embryonic development parameter effects of both drugs in combination with prednisolone (20 µg/ml) were studied using morphological methods, with special attention given to the incidence of malformations. The genotoxic effects of agents evaluated with the TUNEL test revealed that prednisolone is not a cause of developmental toxicity. The maximum safe dose of prednisolone that could be used in combination with other immunosuppressive agents was determined to be 20 µg/ml. Azathioprine was found to be toxic and teratogenic for the rat embryos beginning at a dose of 1 µg/ml. Dose-dependent toxic and teratogenic effects of mycophenolate mofetile were detected at doses lower than normal clinical ones.
Yazarlar (5)
1
Zeliha Fazliogullari
ORCID: 0000-0002-5103-090X
2
Ahmet Kagan Karabulut
3
Nadire Unver Dogan
4
Ismihan Ilknur Uysal
5
Hasan Acar
Anahtar Kelimeler
Azathioprine
mycophenolate mofetile
prednisolone
TUNEL assay
whole embryo culture
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime