Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-İnduced Testicular Tissue Damage
Reproductive Sciences · Ağustos 2024
YÖKSİS Kayıtları
The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-İnduced Testicular Tissue Damage
REPRODUCTIVE SCIENCES · 2024 SCI
PROFESÖR MURAT BOYDAK →
Makale Bilgileri
DergiReproductive Sciences
Yayın TarihiAğustos 2024
Cilt / Sayfa31 · 2433-2446
Scopus ID2-s2.0-85191229719
Erişim🔓 Açık Erişim
Özet
One of the adverse effects of the antineoplastic drug cisplatin (CS) is damage to testicular tissue. This study aimed to examine the potential therapeutic effect of thymoquinone (TQ), a strong antioxidant, against testicular damage caused by CS. In the experiment, 28 rats were used, and the rats were randomly divided into four groups: control (n = 7), CS (n = 7), CS + TQ (n = 7), and TQ (n = 7). The experiment was called off after all treatments were finished on day 15. Blood serum and testicular tissues were utilized for biochemical, histological, immunohistochemical, mRNA expression, and gene protein investigations. The testosterone level decreased and oxidative stress, histopathological damage, dysregulation in mitochondrial dynamics, inflammation and apoptotic cells increased in testicular tissue due to CS administration. TQ supplementation showed anti-inflammatory, antioxidant, and anti-apoptotic effects in response to CS-induced testicular damage. In addition, TQ contributed to the reduction of CS-induced toxic effects by regulating the TNF-α/OTULIN/NF-κB pathway. TQ supplementation may be a potential therapeutic strategy against CS-induced testicular damage by regulating the TNF-α/OTULIN/NF-κB axis, inhibiting inflammation, oxidative stress, and apoptosis.
Yazarlar (7)
1
Tuba Yalçın
ORCID: 0000-0002-2359-9832
2
Sercan Kaya
ORCID: 0000-0001-9014-2448
3
Akın Yiğin
4
Can Ali Ağca
ORCID: 0000-0002-0244-3767
5
Deniz Özdemir
ORCID: 0000-0001-7659-742X
6
Tuncay Kuloğlu
ORCID: 0000-0001-9874-3838
7
M. Boydak
Anahtar Kelimeler
Cisplatin
Nuclear factor kappa B
OTULIN
Testicular damage
Thymoquinone
Tumour necrosis factor-alpha
Kurumlar
Batman University
Batman Turkey
Bingöl Üniversitesi
Bingol Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
7
Yazar
6
Anahtar Kelime