Scopus
YÖKSİS Eşleşti
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · Eylül 2021
YÖKSİS Kayıtları
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
DOÇENT GÜLSÜM ABUŞOĞLU →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR MEHMET KAYNAR →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCİ
PROFESÖR MEHMET KAYNAR →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR ABDULLAH SİVRİKAYA →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
DOKTOR ÖĞRETİM ÜYESİ DUYGU DURSUNOĞLU →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR ABDULLAH SİVRİKAYA →
Is there a relation between serum methylarginine levels and infertility?
Hormone Molecular Biology and Clinical Investigation · 2021 ESCI
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiEylül 2021
Cilt / Sayfa42 · 273-278
Scopus ID2-s2.0-85100449467
Özet
Objectives: Infertility is defined as the absence of pregnancy within the reproductive period despite regular sexual intercourse. Methylarginines are formed as a result of methylation of arginine residues in proteins and formed in three forms as asymmetric dimethyl arginine (ADMA), symmetrical dimethyl arginine (SDMA) and monomethylarginine (L-NMMA). So, here, we aimed to evaluate arginine and their derivatives levels in fertile and infertile individuals. Methods: Present study were consist of 30 oligozoospermia patients (proven by spermiogram analysis) and 30 healthy individuals with normozoospermia group who were applied to the urology department. With blood samples taken from individuals, serum methylarginine and its derivatives levels were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Clinic data and demographic characteristics of individuals were also recorded at the same time. Results: The serum ADMA level (0.38 ± 0.07) of the oligozoospermia group was found to be significantly higher than the normozoospermia group (0.35 ± 0.05) (p=0.046). A positive correlation were observed between ADMA and SDMA (r=0.686, p=0.000), HArg and SDMA (r=0.611, p=0.001), citrulline and L-NMMA (r=0.595, p=0.001) in patients with oligosospermia. The increase in SDMA, arginine and HArg levels and a decrease in L-NMMA and citrulline levels were not significant as statistically. Also, the ADMA level was found to be high in individuals with low sperm concentration. Conclusions: Consequently, serum ADMA levels of individuals with oligozoospermia were statistically significantly higher than those with normozoospermia. As proposal, determination of ADMA levels may be a potential biomarker parameter in terms of early diagnosis of fertility and infertility.
Yazarlar (7)
1
Yasin Saygin
ORCID: 0000-0002-1695-8550
2
Abdullah Sivrikaya
3
Turan Akdağ
ORCID: 0000-0003-3175-6751
4
Duygu Dursunoǧlu
ORCID: 0000-0003-4414-8659
5
Mehmet Kaynar
ORCID: 0000-0002-6957-9060
6
Gulsum Abusoglu
7
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
fertile
infertile
methylarginine
normozoospermia
oligozoospermia
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey