Scopus
YÖKSİS Eşleşti
The effect of volume replacement during therapeutic leukapheresis on white blood cell reduction in patients with extreme leukocytosis
Transfusion · Kasım 2013
YÖKSİS Kayıtları
The effect of volume replacement during therapeutic leukapheresis on white blood cell reduction in patients with extreme leukocytosis
Transfusion · 2013 SCI
PROFESÖR SÜLEYMAN BALDANE →
Makale Bilgileri
DergiTransfusion
Yayın TarihiKasım 2013
Cilt / Sayfa53 · 2629-2634
Scopus ID2-s2.0-84887818649
Özet
Background Extreme leukocytosis, generally defined as a white blood cell (WBC) count of more than 100 × 109/L consisting largely of blast cells, especially when accompanied by clinical signs and symptoms of leukostasis or hyperviscosity, often predicts a poor clinical outcome in patients with acute leukemia. In this study, we aimed to investigate the effect of volume replacement (VR) during therapeutic leukapheresis (TA) procedure on early mortality rate and WBC reduction. Study Design and Methods We retrospectively analyzed 29 patients who underwent TA from 2007 to 2011. Fifteen of the patients underwent TA procedure with VR and 14 of the patients underwent TA procedure without VR. Results WBC reduction was significantly higher in patients who underwent TA with VR (p < 0.001). Early mortality rate was significantly lower in leukemia patients who underwent TA with VR than in patients who underwent TA without VR (p < 0.01); early mortality rates were 6.7% for 7-day and 13.8% for 100-day survivals. The mortality rates in the TA without VR group, however, were 42.9 and 71.4% for 7- and 100-day survivals, respectively. Conclusion Decreased early mortality rate in TA with VR group may be associated with prompt reduction of WBCs achieved with TA with VR and may also be associated with removal of the cytokines related to leukostasis. TA with VR would give more time for induction chemotherapy and increased overall survival rate. © 2013 American Association of Blood Banks.
Yazarlar (11)
1
Fatih Kurnaz
2
Serdar Sivgin
3
Cigdem Pala
4
Rahsan Yildirim
5
Süleyman Baldane
6
Leylagul Kaynar
7
Musa Solmaz
8
Ahmet Öztürk
ORCID: 0000-0002-7130-5624
9
Bulent Eser
10
Mustafa Cetin
11
Ali Ünal
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Harran Üniversitesi
Sanliurfa Turkey
Metrikler
2
Atıf
11
Yazar