Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The serum S100B level as a biomarker of enteroglial activation in patients with ulcerative colitis
International Journal of Inflammation · Ocak 2014
YÖKSİS Kayıtları
The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis
International Journal of Inflammation · 2014 EBSCO, PUBMED, SCOPUS, EMBASE
PROFESÖR SÜLEYMAN BALDANE →
Makale Bilgileri
DergiInternational Journal of Inflammation
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84899529839
Erişim🔓 Açık Erişim
Özet
Objective. Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract. This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients. Methods. This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index. Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits. Results. GFAP was not detected in the serum of either UC patients or controls (P>0.05). However, we found a significant (P<0.001) decrease in the serum S100B levels in the UC patients. No correlation between the serum S100B level and the disease activity or duration was observed (P>0.05). The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (P>0.05). Conclusions. Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients. © 2014 Asuman Celikbilek et al.
Yazarlar (12)
1
Asuman Celikbilek
2
Mehmet Celikbilek
3
Seda Sabah
4
Nermin Tanik
5
Elif Borekci
6
Serkan Dogan
7
Yavuz Akin
8
Süleyman Baldane
9
Kemal Deniz
10
Neziha Yilmaz
11
Omer Ozbakir
12
Mehmet Yucesoy
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Erciyes Üniversitesi
Kayseri Turkey
Metrikler
8
Atıf
12
Yazar