Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Positive effects of oral β-glucan on mucositis and leukopenia in colorectal cancer patients receiving adjuvant FOLFOX-4 combination chemotherapy
Asian Pacific Journal of Cancer Prevention · Ocak 2014
YÖKSİS Kayıtları
Positive Effects of Oral Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX 4 Combination Chemotherapy
Asian Pacific Journal of Cancer Prevention · 2014 SCI-Expanded
PROFESÖR SÜLEYMAN BALDANE →
Makale Bilgileri
DergiAsian Pacific Journal of Cancer Prevention
Yayın TarihiOcak 2014
Cilt / Sayfa15 · 3641-3644
Scopus ID2-s2.0-84901989956
Erişim🔓 Açık Erişim
Özet
The present study aimed to determine the effect of oral β-glucan on mucositis and leukopenia in 62 consecutive patients with colorectal cancer treated with an adjuvant FOLFOX-4 regimen. The patients were retrospectively evaluated in 2 groups: one group received β-glucan and the other did not (control group). Leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy and oral mucositis and diarrhea were noted. Leucocyte and neutrophil counts after chemotherapy in the β-glucan group were 7,300/mm3 and 3,800/mm3, respectively, and the reductions, as compared to baseline, were not significant (p=0.673 and 0.784). The median platelet count was 264,000/mm3 after chemotherapy in the β-glucan group and the reduction, as compared to baseline, was borderline significant (p=0.048). In the control group, reduction in leucocyte, neutrophil, and platelet counts was statistically significant. Oral mucositis and diarrhea were less common in the β-glucan group. We conclude that β-glucan can be used to reduce the adverse effects of chemotherapy.
Yazarlar (10)
1
Halit Karaca
2
Oktay Bozkurt
3
E. Ozaslan
4
Süleyman Baldane
5
Veli Berk
6
Mevlude Inanc
7
Ayse Duran
8
Mustafa Dikilitas
9
Ozlem Er
10
Metin Ozkan
Anahtar Kelimeler
Chemotherapy
Colorectal cancer
Glucan
Mucositis
Neutropenia
β
Kurumlar
Acibadem Kadiköy Hospital
Kadikoy Türkiye
Erciyes University, Faculty of Medicine
Kayseri Turkey
Metrikler
18
Atıf
10
Yazar
6
Anahtar Kelime