Scopus
YÖKSİS DOI Eşleşti
SJR Q4
Examining the relationship between Vitamin D levels and Helicobacter pylori infection and its effect on the hypothalamic-pituitary-adrenal axis in dyspeptic patients
Journal of Experimental and Clinical Medicine Turkey · Ocak 2015
YÖKSİS Kayıtları
Examining the relationship between vitamin D levels and Helicobacter pylori infection and its effect on the hypothalamic pituitary adrenal axis in dyspeptic patients
Journal of Experimental and Clinical Medicine · 2015 TR DİZİN
Prof. Dr. SÜLEYMAN BALDANE →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Digital necrosis caused by a snake bite
2013 ISSN: 13094483 CEPIEC, Crossref, DOAJ, EMBASE, EBSCOhost, Google Scholar, Index Copernicus, J-Gate, NLM Catalog (PubMed), Scopus, Turkiye Citation Index, World Cat
Prof. Dr. HASAN KARA →
Examining the relationship between vitamin D levels and Helicobacter pylori infection and its effect on the hypothalamic pituitary adrenal axis in dyspeptic patients
2015 ISSN: 1309-4483 TR DİZİN
Prof. Dr. SÜLEYMAN BALDANE →
Valproic acid- induced early diagnosed encephalopathy
2014 ISSN: 13094483 CEPIEC, Crossref, DOAJ, EMBASE, EBSCOhost, Google Scholar, Index Copernicus, J-Gate, NLM Catalog(PubMed), Scopus, Turkiye Citation Index, World Cat
Prof. Dr. GÖKHAN ÖZDEMİR →
Predictors of adverse outcomes in pregnant women with intrauterine hematoma
2022 ISSN: 1309-4483 Scopus, EBSCO, DOAJ
Arş. Gör. ZEKİYE SOYKAN SERT →
Effect of inadequate antenatal care during the pandemic on maternal and fetal outcomes
2022 ISSN: 1309-4483 Scopus, EBSCO, DOAJ
Arş. Gör. ZEKİYE SOYKAN SERT →
Investigation of new biomarkers that can be used for the diagnosis of asymptomatic diabetic peripheral artery disease (PAD): Serum netrin-1 levels can be a potential biomarker for the diagnosis of PAD
2024 ISSN: 1309-4483 SCOPUS, EBSCO, EMBASE
Prof. Dr. BAHADIR ÖZTÜRK →
The effect of virtual reality based rehabilitation on cognitive functions in stroke patients: A review
2024 ISSN: 1309-4483 Scopus
Öğr. Gör. MEHMET KAAN ALTUNOK →
Investigation of new biomarkers that can be used for the diagnosis of asymptomatic diabetic peripheral artery disease (PAD): Serum netrin-1 levels can be a potential biomarker for the diagnosis of PAD
2024 ISSN: 1309-4483 Scopus
Prof. Dr. ALİ ÜNLÜ →
Makale Bilgileri
ISSN13094483
Yayın TarihiOcak 2015
Cilt / Sayfa32 · 109-116
Scopus ID2-s2.0-85006677759
Özet
The purpose of this study was to determine whether or not Helicobacter pylori (H. pylori) infection affects the hypothalamic-pituitary-adrenal (HPA) axis and to evaluate the association between vitamin D levels with H. pylori infected and eradicated patients. The glucagon stimulation test (GST) was used to assess the HPA gland axis. An H. pylori infection was diagnosed based on the rapid urease test and histology. All infected patients received triple eradication therapy. Three months after the treatment, 14C urea breath test was reinstituted, and GST was repeated in patients who were negative for H. pylori. Of the 43 patients, 20 (46%) were found to have a lower mean value of peak cortisol than normal responses to the GST in the H. pylori-infected subjects. In 29 subjects, H. pylori infection was successfully eradicated. Twelve (41%) out of 29 subjects were defined as having a blunted GST response and 17 (%59) subjects had normal HPA axis response to GST in the H. pylori-eradicated subjects. A significant correlation between low 25-hydroxyvitamin D3 (25(OH)D3) level and low peak cortisol response to GST was identified in the H. pylori-infected subjects. After H. pylori eradication, the positive correlation between 25(OH)D3 level and high peak cortisol response to GST was also identified. Mean 25(OH)D3 levels were lower in the H. pylori-infected subjects than in the H. pylori-eradicated subjects. Our results indicate an increased prevalence of blunted glucocorticoid response to GST in patients with infected H. pylori. Vitamin D deficiency is also common in the H. pylori-infected subjects and associated with blunted glucocorticoid response. These findings suggest that H. pylori eradication increases the cortisol response to GST. Vitamin D supports adrenal/cortisol production whereby a deficiency can result blunted glucocorticoid response to GST in patients with infected H. pylori.
Yazarlar (6)
1
Huseyin Korkmaz
2
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
3
Süleyman Baldane
4
Mehmet Sözen
ORCID: 0000-0002-8428-1115
5
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
6
Levent Kebapcilar
Anahtar Kelimeler
Cortisol
Dyspeptic patients
Helicobacter pylori
Hypothalamic-pituitary-adrenal axis
Vitamin D
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Experimental and Clinical Medicine (Turkey)
Q4
OA
SJR Skoru0,144
H-Index11
YayıncıOndokuz Mayis Universitesi
ÜlkeTurkey
Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q4)
Medicine (miscellaneous) (Q4)
Metrikler
1
Atıf
6
Yazar
5
Anahtar Kelime