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Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) serum levels in patients with prediabetes and type 2 diabetes

Bratislava Medical Journal · Ocak 2018

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YÖKSİS Kayıtları
Evaluation of Fractalkine (FKN) and Secreted Frizzled-Related Protein 4 (SFRP-4) Serum Levels in Patients with Prediabetes and Type 2 Diabetes
Bratislava Medical Journal · 2018 SCI-Expanded
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Makale Bilgileri

DergiBratislava Medical Journal
Yayın TarihiOcak 2018
Cilt / Sayfa119 · 112-115
DOI10.4149/BLL_2018_021
Scopus ID2-s2.0-85042041679
Erişim🔓 Açık Erişim
Özet OBJECTIVE: The objective of this study is to compare serum levels of FKN and SFRP-4 in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). METHODS: A total of 152 patients presented to the endocrinology outpatient clinic of our hospital were included in the study. Eighty-two patients with a history of T2DM were assigned to the T2DM group. IGT (n = 34) and NGT (n = 36) groups included the patients who received oral glucose tolerance test outcomes. RESULTS: Serum FKN levels were significantly higher in the IGT and T2DM groups compared to the NGT group (p < 0.001 and p < 0.001, respectively). Serum SFRP-4 levels were significantly higher in the T2DM group compared to the IGT and NGT groups (p = 0.001 and p = 0.004, respectively). A significant correlation was observed between FKN and fasting glucose levels. SFRP-4 was significantly correlated with fasting glucose, HbA1c, and triglyceride levels. CONCLUSION: To our knowledge, increased FKN levels in patients with IGT were demonstrated for the first time in this study. The results of our study support the opinion that FKN and SFRP-4 may contribute to the pathogenesis of T2DM (Tab. 1, Fig. 3, Ref. 23).

Yazarlar (6)

1
Süleyman Baldane
2
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
3
A. Ekin
4
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Levent Kebapcilar

Anahtar Kelimeler

Fractalkine Inflammation Insulin secretion Secreted frizzled-related protein 4

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
T. C. Sağlık Bakanlığı, Bingol Devlet Hastanesi
Bingol Turkey

Metrikler

14
Atıf
6
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

SB
SÜLEYMAN BALDANE
PROFESÖR

Hızlı Erişim

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