Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of glucose ingestion on serum fractalkine levels in healthy subjects and newly diagnosed type 2 diabetic patients
Journal of Medical Biochemistry · Temmuz 2018
YÖKSİS Kayıtları
EFFECTS OF GLUCOSE INGESTION ON SERUM FRACTALKINE LEVELS IN HEALTHY SUBJECTS AND NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS
Journal of Medical Biochemistry · 2018 SCI-Expanded
PROFESÖR SÜLEYMAN BALDANE →
EFFECTS OF GLUCOSE INGESTION ON SERUM FRACTALKINE LEVELS IN HEALTHY SUBJECTS AND NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS
Journal of Medical Biochemistry · 2018 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Effects of Glucose Ingestion on Serum Fractalkine Levels in Healthy Subjects and Newly Diagnosed Type 2 Diabetic Patients
Journal of Medical Biochemistry · 2018 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Effects of Glucose Ingestion on Serum Fractalkine Levels in Healthy Subjects and Newly Diagnosed Type 2 Diabetic Patients
Journal of Medical Biochemistry · 2018 Endekste taranmıyor
PROFESÖR ALİ ÜNLÜ →
Effects of Glucose Ingestion on Serum Fractalkine Levels in Healthy Subjects and Newly Diagnosed Type 2 Diabetic Patients
Journal of Medical Biochemistry · 2018 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Makale Bilgileri
DergiJournal of Medical Biochemistry
Yayın TarihiTemmuz 2018
Cilt / Sayfa37 · 373-378
Scopus ID2-s2.0-85063239798
Erişim🔓 Açık Erişim
Özet
Background: Fractalkine (FKN) is an inflammatory cytokine that has been shown with increased serum levels in diabetic patients and is considered to contribute to the adipose tissue inflammation by supporting monocyte adhesion to adipocytes which has an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to evaluate the effects of glucose ingestion on the serum fractalkine levels in healthy subjects with normal glucose tolerance (NGT) and newly diagnosed T2DM patients. Methods: A total of 67 patients were included in this study, and they were divided into NGT (n=34) and T2DM (n=33) groups according to their oral glucose tolerance test (OGTT) results. The serum FKN and C-reactive protein (CRP) levels were measured at 0 and 120 minutes during an OGTT following overnight fasting. Results: The 0-minute (basal) and 120-minute OGTT FKN levels were found to be significantly higher in the T2DM group when compared to the NGT group (p=0.012 and p=0.001, respectively). However, no significant differences were observed in terms of the changes in the basal and 120-minute OGTT FKN levels in the T2DM and NGT groups (p=0.433 and p=0.06, respectively). A significant positive correlation was observed between the 120-minute OGTT FKN and glucose levels in the study group consisting of all of the patients (r=0.331, p=0.006). Conclusions: In this study, basal and post-glycemic load FKN levels were found to be higher in newly diagnosed T2DM patients than those with NGT; however, there was no additional change in FKN levels by glycemic load.
Yazarlar (7)
1
Süleyman Baldane
2
Ismail Can Kendir
3
Cem Onur Kirac
4
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
5
G. Tekin
6
Ali Ünlü
ORCID: 0000-0002-9991-3939
7
Levent Kebapcilar
Anahtar Kelimeler
Fractalkine
Inflammation
Oral glucose tolerance test
Type 2 diabetes mellitus
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
11
Atıf
7
Yazar
4
Anahtar Kelime