Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effect of vitamin d deficiency on the frequency of lipohypertrophy occurrence in patients with type 2 diabetes mellitus under injectable treatment
Turkish Journal of Endocrinology and Metabolism · Ocak 2020
YÖKSİS Kayıtları
Effect of Vitamin D Deficiency on the Frequency of Lipohypertrophy Occurrence in Patients with Type 2 Diabetes Mellitus Under Injectable Treatment.
Turkish Journal of Endocrinology and Metabolism · 2020 E-SCI
Prof. Dr. SÜLEYMAN BALDANE →
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Makale Bilgileri
ISSN13012193
Yayın TarihiOcak 2020
Cilt / Sayfa24 · 184-188
Scopus ID2-s2.0-85091191345
Erişim🔓 Açık Erişim
Özet
Objective: Lipohypertrophy (LH) is one of the most common treatment-related cutaneous complications of injectable therapies. Although the etiology of LH cannot be clarified, it may be due to the lipogenic effect of insulin or recurrent tissue trauma caused by injections. In this respect, we aimed to evaluate the relationship between vitamin D level and LH. Material and Methods: Patients with Type 2 diabetes mellitus aged 18 years or older, who were under insulin and/or exenatide treatment for at least one year were included in this study. The injection sites of the patients were examined by inspection and palpation method. Patients were catego-rized into two groups according to vitamin D levels as below and above 20 ng/mL. Results: A total of 140 patients, including 91 women and 49 men, aged between 20-78 years with a mean age of 54.53±13.89 were included in the study. LH was detected in 91 (65%) of 140 patients. This study de-monstrated that there was a significant relationship between gender and LH. Statistically, the frequency of LH was higher in female patients (p=0.001). Further, a relationship between vitamin D levels and LH was also observed (p=0.006). Conclusion: Besides calcium metabolism, the effects of vitamin D on lipogenesis are also known. Vitamin D inhibits the differentiation of pre-adipocytes to mature adipocytes. This is the first study showing the relationship between vitamin D and LH in our knowledge.
Yazarlar (4)
1
Cem Onur Kirac
2
Cuma Gönüllü
3
Süleyman Baldane
4
Levent Kebapcilar
Anahtar Kelimeler
Diabetes mellitus
Exenatide
Insulin treatment
Lipohypertrophy
Vitamin D
Kurumlar
Kahramanmaras Necip Fazil City Hospital
Kahramanmaras Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Endocrinology and Metabolism
Q4
OA
SJR Skoru0,121
YayıncıAVES Ibrahim KARA
ÜlkeTurkey
Endocrinology, Diabetes and Metabolism (Q4)
Internal Medicine (Q4)
Metrikler
3
Atıf
4
Yazar
5
Anahtar Kelime