Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Value of Immunoscore in Thyroid Carcinoma
Turk Onkoloji Dergisi · Ocak 2023
YÖKSİS Kayıtları
Value of Immunoscore in Thyroid Carcinoma
TURKISH JOURNAL of ONCOLOGY · 2023 Emerging Sources Citation Index
Prof. Dr. SÜLEYMAN BALDANE →
Value of Immunoscore in Thyroid Carcinoma
Turkish Journal of Oncology · 2023 ESCI
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
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2017 ISSN: 13007467 ESCI
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2021 ISSN: 1300-7467 ESCI
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Are Hormonal Agents Better Than Chemo in Metastatic Castration-resistant Prostate Cancer?
2021 ISSN: 1300-7467 emerging SCI
Dr. Öğr. Üyesi SERKAN YILDIRIM →
Value of Immunoscore in Thyroid Carcinoma
2023 ISSN: 1300-7467 ESCI
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Value of Immunoscore in Thyroid Carcinoma
2023 ISSN: 1300-7467 Emerging Sources Citation Index
Prof. Dr. SÜLEYMAN BALDANE →
Guide for Quality Control and Quality Assurance Tests in Image-guided Radiotherapy Systems
2024 ISSN: 1300-7467 ESCI
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Makale Bilgileri
Dergi
Turk Onkoloji Dergisi
ISSN13007467
Yayın TarihiOcak 2023
Cilt / Sayfa38 · 127-135
Scopus ID2-s2.0-85161402595
Erişim🔓 Açık Erişim
Özet
OBJECTIVE Thyroid cancer is the most common endocrine neoplasm. About 10% develop invasive disease and 5% lymph node (LN) metastasis. An alternative immunoscore system to the tumor node metastasis (TNM) classification has been developed to predict the prognosis of solid tumors. The aim of this study is to in-vestigate the potential roles of CD3+, CD8+ T lymphocyte infiltration and programmed death-ligand 1 (PD-L1) expression in immunoscore, the prognostic value of Immunoscore for Papillary thyroid cancer and its support for TNM classification. METHODS A total of 164 patients diagnosed with papillary thyroid cancer were included in our study. Immunoscore was evaluated by immunohistochemistry according to CD3+ and CD8+ T lymphocyte density at the tumor center and at the tumor margin. Immunoscore values were calculated. PD-L1 was evaluated by immunohistochemistry according to its density at the tumor center and at the tumor margin. The rela-tionships between the parameters studied were evaluated statistically. RESULTS The presence of PD-L1 at the tumor centers in CD8+ T lymphocytes height was also significantly higher (p<0.001). There was no significant relationship between PD-L1 expression at the tumor center and LN metastasis and tumor size (p>0.999 and p=0.226, respectively). In the presence of PD-L1 expression at the tumor margin, LN metastasis (p<0.001) and tumor size (p=0.029) were higher. PD-L1 expression at the tumor margin was significantly associated with overall survival (p<0.001). CONCLUSION In particular, immunoscore value can be a good prognostic marker and its significant association with conditions associated with poor prognosis, such as PD-L1 expression, suggests that it may be a parame-ter that can be used and guided in stage scoring.
Yazarlar (4)
1
Ceyhan Uğurluoğlu
2
Süleyman Baldane
3
M. K. Korez
ORCID: 0000-0001-9524-6115
4
Mesut Bayer
Anahtar Kelimeler
Immunoscore
papillary thyroid cancer
prognosis
programmed death-ligand 1
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turk Onkoloji Dergisi
Q4
SJR Skoru0,130
H-Index10
YayıncıIstanbul Tip Fakultesi
ÜlkeTurkey
Oncology (Q4)