Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Predictive Values of Respiratory Rate Oxygenation Index and Chest Computed Tomography Severity Score for High-Flow Nasal Oxygen Failure in Critically Ill Patients with Coronavirus Disease-2019
Balkan Medical Journal · Ocak 2022
YÖKSİS Kayıtları
The Predictive Values of Respiratory Rate Oxygenation Index and Chest Computed Tomography Severity Score for High-Flow Nasal Oxygen Failure in Critically Ill Patients with Coronavirus Disease-2019
Balkan Medical Journal · 2022 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ FAHREDDİN KALKAN →
The Predictive Values of Respiratory Rate Oxygenation Index and Chest Computed Tomography Severity Score for High-Flow Nasal Oxygen Failure in Critically Ill Patients with Coronavirus Disease-2019
Balkan Medical Journal · 2022 SCI-Expanded
DOÇENT YUNUS AKDOĞAN →
Makale Bilgileri
DergiBalkan Medical Journal
Yayın TarihiOcak 2022
Cilt / Sayfa39 · 140-147
Scopus ID2-s2.0-85127023573
Erişim🔓 Açık Erişim
Özet
Background: The prediction of high-flow nasal oxygen (HFNO) failure in patients with coronavirus disease-2019 (COVID-19) having acute respiratory failure (ARF) may prevent delayed intubation and decrease mortality. Aims: To define the related risk factors to HFNO failure and hospital mortality Study Design: Retrospective cohort study. Methods: To this study, 85 critically ill patients (≥18 years) with COVID-19 related acute kidney injury who were treated with HFNO were enrolled. Treatment success was defined as the de-escalation of the oxygenation support to the conventional oxygen therapies. HFNO therapy failure was determined as the need for invasive mechanical ventilation or death. The patients were divided into HFNO-failure (HFNO-F) and HFNO-success (HFNO-S) groups. Electronic medical records and laboratory data were screened for all patients. Respiratory rate oxygenation (ROX) index on the first hour and chest computed tomography (CT) severity score were calculated. Factors related to HFNO therapy failure and mortality were defined. Results: This study assessed 85 patients (median age 67 years, 69.4% male) who were divided into two groups as HFNO success (n = 33) and HFNO failure (n = 52). The respiratory rate oxygenation (ROX) was measured at 1 hour and the computed tomography (CT) score indicated HFNO failure and intubation, with an area under the receiver operating characteristic of 0.695 for the ROX index and 0.628 for the CT score. A ROX index of <3.81 and a CT score of >15 in the first hour of therapy were the predictors of HFNO failure and intubation. Age, Acute Physiology and Chronic Health Evaluation II score, arterial blood gas findings “(i.e., partial pressure of oxygen [PaO2 ], PaO2 [fraction of inspired oxygen]/SO2 [oxygen saturation] ratio)”, and D-dimer levels were also associated with HFNO failure; however, based on logistic regression analysis, a calculated ROX on the first hour of therapy of <3.81 (odds ratio [OR] = 4.78, 95% confidence interval [CI] = 1.75–13.02, P = 0.001) and a chest CT score of >15 (OR = 2.83, 95% CI = 1.01–7.88, P = <0.001) were the only independent risk factors. In logistic regression analysis, a ROX calculated on the first hour of therapy of <3.81 (OR = 4.78, [95% CI = 1.75–13.02], P = 0.001) and a chest CT score of >15 (OR 2.83, 95% CI = 1.01–7.88, P = <0.001) were the independent risk factors for the HFNO failure.
Yazarlar (11)
1
Murat Küçük
ORCID: 0000-0003-1705-645X
2
Begüm Ergan
ORCID: 0000-0003-2920-9214
3
Mehmet Nuri Yakar
ORCID: 0000-0002-3542-3906
4
Bişar Ergün
ORCID: 0000-0003-4828-7576
5
Yunus Akdoğan
6
Ali Cantürk
ORCID: 0000-0001-6145-7029
7
Naciye Sinem Gezer
ORCID: 0000-0002-0868-4545
8
Fahreddin Kalkan
9
Erdem Yaka
ORCID: 0000-0002-6644-4240
10
Bilgin Cömert
ORCID: 0000-0002-2148-5356
11
Necati Ali Gökmen
ORCID: 0000-0002-3225-7666
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
11
Yazar