Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Boric Acid Reverses Nicotine-Induced Cytokine Expressions of Human Gingival Fibroblasts
Biological Trace Element Research · Mart 2023
YÖKSİS Kayıtları
Boric Acid Reverses Nicotine-Induced Cytokine Expressions of Human Gingival Fibroblasts
Springer Science and Business Media LLC · 2022 SCI-Expanded
Prof. Dr. SEMA HAKKI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Investigation of the Relationship Between Serum Trace Elements and MSFC Levels in Multiple Sclerosis: A Cross-sectional Case-Control Study
2025 ISSN: 0163-4984 SCI
Dr. Öğr. Üyesi CİHAT ÖZGÜNCÜ →
Effects of Zinc Deficiency and Supplementation on Malondialdehyde and Glutathione Levels in Blood and Tissues of Rats Performing Swimming Exercise
2003 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effect of Selenium Supplementation on Lipid Peroxidation Antioxidant Enzymes and Lactate Levels in Rats Immediately After Acute Swimming Exercise
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effects of dietary cadmium and boron supplementation on performance eggshell quality and mineral concentrations of bone in laying hens
2015 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. OSMAN OLGUN →
Serum and Cerebrospinal Fluid Magnesium Levels Glasgow Coma Scores and In Hospital Mortality in Patients with Acute Stroke
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Magnesium Sulfate in Emergency Department Patients with Hypertension
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Levels of Selenium Zinc Copper and Cardiac Troponin I in Serum of Patients with Acute Coronary Syndrome
2013 ISSN: 0163-4984 SSCI
Prof. Dr. HASAN KARA →
Elements in Sera of Elite Taekwondo Athletes Effects of Vitamin E Supplementation
2011 ISSN: 0163-4984 SCI 3 atıf
Prof. Dr. EKREM BOYALI →
The Effect of Vitamin A Supplementation on Various Elements in Elite Taekwondo Players
2011 ISSN: 0163-4984 SCI 2 atıf
Prof. Dr. EKREM BOYALI →
Effects of Exercise and Zinc Supplementation on Cytokine Release in Young Wrestlers
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Intraperitoneal Selenium Administration on Liver Glycogen Levels in Rats Subjected to Acute Forced Swimming
2011 ISSN: 0163-4984 SSCI
Prof. Dr. MEHMET KILIÇ →
Effects of Acute Swimming Exercise on Some Elements in Rats
2009 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effects of Chronic Fluorosis on Electrocardiogram in Sheep
2003 ISSN: 0163-4984 SCI-Expanded 24 atıf
Prof. Dr. NURCAN DÖNMEZ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded 10 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Testosterone Levels in Athletes at Rest and Exhaustion Effects of Calcium Supplementation
2009 ISSN: 0163-4984 SCI-Expanded 3 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion
2011 ISSN: 0163-4984 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissue of rats performing swimming exercise
2003 ISSN: 0163-4984 SCI-Expanded 18 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effects of exercise and zinc supplementation on cytokine release in young wrestlers
2011 ISSN: 0163-4984 SSCI 4 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc supplementation on the element distribution in kidney tissue of diabetic rats subjected to acute swimming
2012 ISSN: 0163-4984 SSCI 5 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Makale Bilgileri
ISSN01634984
Yayın TarihiMart 2023
Cilt / Sayfa201 · 1174-1180
Scopus ID2-s2.0-85128420382
Özet
Nicotine, the major bioactive ingredient in tobacco, is a major risk factor for periodontal disease and destruction. Nicotine has been shown to stimulate the production of cytokines that are priming agents for inflammation that induces tissue destruction, such as IL-1β, IL-6, and IL-8, by gingival keratinocytes and human gingival fibroblasts (HGF). Boron as boric acid has been found to decrease pro-inflammatory cytokines and increase anti-inflammatory cytokines in cells with inflammatory stress. Thus, a study was performed to determine whether boric acid reverses negative effects of nicotine on human gingival fibroblasts (HGFs). The viability and cytokine expressions of HGFs cultured for 24 and 72 h in control medium with no nicotine or boric acid added and in media containing only nicotine, only boric acid, or a combination of BA and nicotine were determined. Nicotine in concentrations of 10−1, 10−2, 10−3,10−4, 10−5, and 10–6 mM significantly reduced cell viability compared to the control. Boric acid at 10 and 50 ng/mL in the media partially restored and 100 ng/mL in the media fully restored the nicotine-depressed HGF cell viability to the same level as the control group. Nicotine elevated the expression of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, IL-8, and IL-17 and decreased the anti-inflammatory IL-10 in HGFs at 24 and 72 h. Boric acid at 100 ng/mL in the medium prevented the changes induced by nicotine alone. The findings indicate that boric acid can inhibit or reverse nicotine-induced pathology in periodontal tissue and thus may help maintain oral and periodontal health in tobacco users.
Yazarlar (3)
1
Şerife Buket Bozkurt
2
Forrest H. Nielsen
3
Sema S. Hakkı
Anahtar Kelimeler
Boric acid
Cytokine
Human gingival fibroblast
Nicotine
Kurumlar
Niğde Ömer Halisdemir University
Nigde Turkey
Research Nutritionist Consultant
Grand Forks United States
Selçuk Üniversitesi
Selçuklu Turkey
University of Michigan School of Dentistry
Ann Arbor United States
Scimago Dergi (ISSN Eşleşmesi)
Biological Trace Element Research
Q1
OA
SJR Skoru0,810
H-Index110
YayıncıSpringer
ÜlkeUnited States
Inorganic Chemistry (Q1)
Biochemistry (Q2)
Biochemistry (medical) (Q2)
Clinical Biochemistry (Q2)
Endocrinology, Diabetes and Metabolism (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
4
Atıf
3
Yazar
4
Anahtar Kelime