Scopus
YÖKSİS Eşleşti
Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis
Pediatrics International · Ağustos 2015
YÖKSİS Kayıtları
Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis
Pediatrics International · 2015 SCI-Expanded
DOÇENT MURAT KONAK →
Total antioxidant and total oxidant states, and serum paraoxonase-1 inneonatal sepsis
Pediatrics International · 2015 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
Makale Bilgileri
DergiPediatrics International
Yayın TarihiAğustos 2015
Cilt / Sayfa57 · 608-613
Scopus ID2-s2.0-84940475437
Özet
Background Paraoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. Methods A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. Results In the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). Conclusion Low serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.
Yazarlar (10)
1
Ali Annagür
2
Rahmi Örs
3
Huseyin Altunhan
4
Sevil Kurban
5
Sabahattin Ertuʇrul
6
Murat Konak
7
Saime Sundus Uygun
8
S. Pekcan
9
Ekrem Erbay
10
Idris Mehmetoʇlu
Anahtar Kelimeler
neonatal sepsis
oxidative stress index
paraoxonase-1
total antioxidant state
total oxidant state
Kurumlar
Abant Izzet Baysal University, Faculty of Medicine
Bolu Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
20
Atıf
10
Yazar
5
Anahtar Kelime