Scopus
YÖKSİS Eşleşti
Epidemiology and Outcomes of Neonatal Meningitis Results of the Turkish Neo-Meningitis Nationwide Study
Pediatric Infectious Disease Journal · Nisan 2024
YÖKSİS Kayıtları
Epidemiology and Outcomes of Neonatal Meningitis: Results of the Turkish Neo-Meningitis Nationwide Study
Pediatric Infectious Disease Journal · 2024 SCI-Expanded
DOÇENT MURAT KONAK →
Makale Bilgileri
DergiPediatric Infectious Disease Journal
Yayın TarihiNisan 2024
Cilt / Sayfa43 · 365-370
Scopus ID2-s2.0-85187208247
Özet
Objective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study. Method: Twenty-seven centers from 7 geographical regions participated in the study. Newborns with a positive cerebrospinal fluid culture and/or cerebrospinal fluid polymerase chain reaction were included in the study. Demographic characteristics, clinical, laboratory and neuroimaging findings and mortality characteristics were analyzed. Results: A total of 634 confirmed cases of neonatal meningitis were included in the final analysis. The incidence was 2.51 per 1000 intensive care unit hospitalizations and mortality was observed in 149 (23.5%). Gram-positive bacteria were the predominant pathogens (54.5%), with coagulase-negative Staphylococci accounting for 45.3% of the cases, followed by Gram-negative organisms (37.3%). Viral and fungal organisms were isolated in 3.2% and 1.7% of the infants, respectively. Gram-negative culture growth was more common in infants who died (51% vs. 34.6%; P < 0.001). In the multivariable model, the odds of mortality was higher in those with respiratory distress requiring invasive ventilatory support [odds ratio (OR): 10.3; 95% confidence interval (CI): 4.9–21.7; P < 0.01], hypotension requiring inotropes (OR: 4.4; 95% CI: 2.7–7.1; P < 0.001), low birth weight status (OR: 2.5; 95% CI: 1.4–4.6; P = 0.002), lack of exposure to antenatal steroids (OR: 2.4; 95% CI: 1.3–4.4; P = 0.005) and the presence of concomitant sepsis (OR: 1.9; 95% CI: 1.1–3.2; P = 0.017). Conclusions: In this nationwide study, neonatal meningitis was found to be associated with high mortality. Coagulase-negative Staphylococci was the most common causative microorganism followed by Gram-negative bacteria. Severe clinical presentation with invasive mechanical ventilation and inotrope requirement, as well as concomitant sepsis, low birth weight status and lack of exposure to antenatal steroids, were found to be independent risk factors for mortality.
Yazarlar (50)
1
Mehmet Yekta Oncel
2
Mehmet N. Cizmeci
3
Eda Karadag Oncel
4
Aysegul Elvan-Tuz
5
Fuat Emre Canpolat
6
Mustafa Ali Akin
7
Sinan Uslu
8
Merih Çetinkaya
9
Ömer Erdeve
10
Esin Koc
11
Gulsum Kadioglu-Simsek
12
Mehmet Buyuktiryaki
13
Ferhan Iren Karal
14
Evrim Kiray-Bas
15
Emre Dincer
16
Huseyin Ustun
17
Ipek Guney Varal
18
Pelin Dogan
19
Mahmut Celik
20
Elif Erol
21
Nihal Demirel
22
Betul Tokgoz-Cuni
23
Emel Okulu
24
Turan Lacinbala
25
Ibrahim Murat Hirfanoglu
26
Melda Tas
27
Şahin Takcı
28
Gaye Kocatepe
29
Ayşegül Zenciroğlu
ORCID: 0000-0002-3488-4962
30
Duygu Bidev
31
Ramazan Ozdemir
32
Ismail Kursad Gokce
33
Nilufer Okur
34
Sadik Yurttutan
35
Murat Konak
36
Alper Aykanat
37
Sertaç Arslanoğlu
38
Burak Deliloglu
39
Aybuke Yazıcı
40
Ferit Kulalı
41
Damla Gunes
42
Ezgi Yangin-Ergon
43
Abdullah Baris Akcan
44
Sema Arayici
45
Mustafa Dilek
46
Suzan Sahin
47
Defne Engür-Karasimav
48
Nisel Yilmaz
49
Dilek Yilmaz
50
Ferhan Elmali
Anahtar Kelimeler
epidemiology
meningitis
mortality
newborn
outcomes
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Aydın Gynecology and Pediatrics Hospital
Aydin Türkiye
Başakşehir Çam and Sakura City Hospital
Istanbul Turkey
Bolu Abant İzzet Baysal Üniversitesi
Bolu Turkey
Çanakkale Onsekiz Mart Üniversitesi
Canakkale Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Eskişehir Osmangazi Üniversitesi
Eskisehir Turkey
Gazi Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Istanbul Medeniyet University
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kahramanmaras Sütçü Imam Üniversitesi
Kahramanmaras Turkey
Neonatal Clinic
Izmir Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Sisli Hamidiye Etfal Training and Research Hospital
Istanbul Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
The Hospital for Sick Children
Toronto Canada
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
1
Atıf
50
Yazar
5
Anahtar Kelime