Scopus
YÖKSİS Eşleşti
Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress
Cell Biochemistry and Biophysics · Haziran 2023
YÖKSİS Kayıtları
Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress
Springer Science and Business Media LLC · 2023 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ BURAK DAĞDELEN →
Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress
Cell Biochemistry and Biophysics · 2023 SCI
ARAŞTIRMA GÖREVLİSİ BURAK DAĞDELEN →
Makale Bilgileri
DergiCell Biochemistry and Biophysics
Yayın TarihiHaziran 2023
Cilt / Sayfa81 · 299-311
Scopus ID2-s2.0-85147751715
Özet
This study was conducted to compare the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Increased Il-1 and Il-6 expressions, markers of inflammation, were represented by inflammation models in mouse liver and kidney tissues injected intraperitoneally with LPS. After establishing the model, the GSH level and the GSH/GSSG ratio, which are oxidative stress markers, were investigated in both tissues treated with LPS and the control group. The expression of Trx1, TrxR, and Txnip genes increased in the liver tissues of LPS-treated mice. In the kidney tissue, while Trx1 expression decreased, no change was observed in TrxR1 expression, and Txnip expression increased. In the kidneys, TRXR1 and GR activities decreased, whereas GPx activity increased. In both tissues, the TRXR1 protein expression decreased significantly, while TXNIP expression increased. In conclusion, different behaviors of antioxidant system members were observed during acute inflammation in both tissues. Additionally, it can be said that the kidney tissue is more sensitive and takes earlier measures than the liver tissue against cellular damage caused by inflammation and inflammation-induced oxidative stress.
Yazarlar (4)
1
Berna Hukkamlı
ORCID: 0000-0001-6923-7522
2
Burak Dağdelen
ORCID: 0000-0002-4362-3852
3
Feyza Sönmez Aydın
ORCID: 0000-0002-8027-5973
4
Harun Budak
ORCID: 0000-0002-7371-8959
Anahtar Kelimeler
Expression and activity
Glutathione system
Inflammation
Oxidative stress
Thioredoxin system
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Doğuş Üniversitesi Istanbul
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
Sinop Üniversitesi
Sinop Turkey
Metrikler
3
Atıf
4
Yazar
5
Anahtar Kelime