Sporadic creutzfeldt-jakob disease in the differential diagnosis of psychiatric disorders: Two case reports

Haseki Tip Bulteni · Eylül 2018

YÖKSİS Kayıtları

Psikiyatrik Bozuklukların Ayırıcı Tanısında Sporadik Creutzfeldt-Jakob Hastalığı: İki Olgu Sunumu. / Sporadic Creutzfeldt-Jakob Disease in the Differential Diagnosis of Psychiatric Disorders: Two Case Reports

Medical Bulletin of Haseki · 2018 ESCI: Emerging Sources Citation Index

DOÇENT AHMET HAKAN EKMEKCİ →

Sporadic Creutzfeldt-Jakob Disease in the Differential Diagnosis of Psychiatric Disorders: Two Case Reports

Medical Bulletin of Haseki · 2018 ESCI

DOÇENT AHMET HAKAN EKMEKCİ →

Sporadic Creutzfeldt-Jakob Disease in the Differential Diagnosis of Psychiatric Disorders: Two Case Reports

Medical Bulletin of Haseki · 2018 Emerging Sources Citation Index (ESCI)

DOÇENT FETTAH EREN →

Sporadic Creutzfeldt-Jakob Disease in the Differential Diagnosis of Psychiatric Disorders: Two Case Reports

Medical Bulletin of Haseki · 2018 ESCI

PROFESÖR ŞEREFNUR ÖZTÜRK →

Makale Bilgileri

DergiHaseki Tip Bulteni

Yayın TarihiEylül 2018

Cilt / Sayfa56 · 252-255

DOI10.4274/haseki.99609

Scopus ID2-s2.0-85053672822

Erişim🔓 Açık Erişim

Özet Creutzfeldt-Jakob disease (CJD) is a prion disease manifesting with signs of impaired conscious and mental state, cerebellar ataxia, myoclonus, and loss of vision. Since the disease progresses rapidly to death, it is important to distinguish it from other diseases. The exact diagnosis is made by postmortem histopathological analysis of the brain. The diagnosis of CJD is difficult because the clinical presentation varies between cases. In this paper, we present two cases of CJD. The first case was a 50-year-old male who was admitted with agitation, impaired consciousness and involuntary movements for three months. The second case was a 70-year-old male presented with forgetfulness, total loss of vision in the form of conversion disorder and ataxia. Diagnostic support was provided by magnetic resonance imaging (MRI) and electroencephalography (EEG). Increased cerebrospinal fluid concentration of 14.3.3 protein was determined. As a result, prion disease was considered in these cases due to rapid progression of the neuropsychiatric symptoms. Repeated EEG and MRI are useful for diagnosis in these patients. Although there is not effective treatment, diagnosis of the condition is very important in terms of preventive measures.