Scopus
YÖKSİS Eşleşti
A rich source of natural compounds: comprehensive research on biological properties of Lamium orientale
Plant Biosystems · Ocak 2025
YÖKSİS Kayıtları
A rich source of natural compounds: comprehensive research on biological properties of Lamium orientale
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology · 2025 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiPlant Biosystems
Yayın TarihiOcak 2025
Cilt / Sayfa159 · 302-315
Scopus ID2-s2.0-105001482050
Özet
Lamium orientale E.H.L. Krause is a herbaceous annual plant species in the Lamiaceae family. In the present study, anticancer, antioxidant, antibacterial, enzyme inhibitory, and quorum sensing inhibitory (on the inhibition of biofilm formation and violacein pigment production) activities of infusion and methanol (MeOH) extracts of roots, stems, leaves, and flowers of L. orientale were evaluated. The total phenolic-flavonoid contents and the phytochemical profiles of the extracts were determined using colorimetric assays and high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS), respectively. The leaf extracts had the maximal levels of flavonoids and phenolics. Chlorogenic acid was most concentrated in the extracts. Based on several antioxidant activity assays, the MeOH extract of the flowers and infusion extract of the leaves had potent antioxidant activities. The MeOH extract of the stems exhibited the highest activities against acetylcholinesterase and butyrylcholinesterase, while the MeOH extract of the roots demonstrated the highest activities against tyrosinase, amylase, and glycosidase. The highest anticancer activity was determined for the MeOH extract of the roots against the MCF-7 cells (IC50=425.7 µg/mL). The MeOH extract of leaves and all infusion extracts significantly inhibited biofilm formation in Pseudomonas aeruginosa. The results suggested that L. orientale extracts may have significant potential for developing new therapeutic approaches owing to their high content of bioactive molecules.
Yazarlar (11)
1
Enis Fuat Tüfekci
2
Ebrar Çağlıyan
3
Gamze Burcu Balcı
4
Yasemin Celik Altunoglu
5
Nilufar Nilofar
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
8
Diletta Piatti
ORCID: 0009-0001-9590-5560
9
Massimo Ricciutelli
10
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
11
Mehmet Cengiz Baloglu
Anahtar Kelimeler
Antioxidant activity
biofilm
cell viability
enzyme inhibitors
Lamium orientale
plant extracts
Kurumlar
Kastamonu University
Kastamonu Turkey
Sabancı Üniversitesi
Tuzla Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Camerino
Camerino Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy