Scopus
YÖKSİS Eşleşti
Pediatric Varicella-related Hospitalization in Turkey Between 2008 and 2018: Impact of Universal Single Dose Varicella Vaccine (VARICOMP Study)
Pediatric Infectious Disease Journal · Ocak 2025
YÖKSİS Kayıtları
Pediatric Varicella-related Hospitalization in Turkey Between 2008 and 2018: Impact of Universal Single Dose Varicella Vaccine (VARICOMP Study)
Pediatric Infectious Disease Journal · 2025 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Pediatric Varicella-related Hospitalization in Turkey Between 2008 and 2018: Impact of Universal Single Dose Varicella Vaccine (VARICOMP Study)
Pediatric Infectious Disease Journal · 2025 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Makale Bilgileri
DergiPediatric Infectious Disease Journal
Yayın TarihiOcak 2025
Cilt / Sayfa44 · 83-89
Scopus ID2-s2.0-85213597030
Özet
Background: A single-dose varicella vaccine at 12 months of age was introduced to the National Immunization Program in February 2013 in Turkey. This study aimed to evaluate varicella-related hospitalization in children and the impact of a single-dose live attenuated varicella vaccine over the first 5.5 years of introducing a universal varicella vaccination. Methods: We analyzed data collected from the medical records of children <18 years old who required hospitalization due to varicella in 17 cities representing 50% of the childhood population in Turkey between 2008 and 2018. We calculated the rate of hospitalization for varicella per 100,000 children during the study period. The main objective of this study was to determine the yearly rate of hospitalization due to varicella and to compare these rates in the pre-vaccine and post-vaccine periods. The secondary objective was to compare demographic features, varicella-related complications, and outcomes between the pre-vaccine and post-vaccine periods. Results: A total of 4373 children (2458 boys and 1915 girls; 72.3% previously healthy) were hospitalized for varicella over a 10-year period, including 2139 children during the pre-vaccine period and 2234 children during the post-vaccine period. Overall, varicella hospitalization rates decreased significantly after the introduction of varicella vaccination [pre-vaccine vs. post-vaccine period; 3.79 vs. 2.87 per 100,000 per year; P < 0.001; odds ratio 0.75; 95% confidence interval 0.64-0.88]. The incidence of varicella-related hospitalization among children between 1 and 5 years of age was significantly lower in the post-vaccine era than in the pre-vaccine era, with a 60.2% decrease in hospitalizations (2.43 vs. 6.12 per 100,000 children; P < 0.001, odds ratio 0.39; 95% confidence interval 0.34-0.46). In both the <1-year and 6- to 10-year age groups, the incidence of varicella-related hospitalizations was similar in the pre-vaccine and post-vaccine periods. The incidence of varicella-related hospitalization was higher in the post-vaccine era among 11-15 years and >15-year-old groups (P < 0.01 and P < 0.05). The mean age was higher during the post-vaccine period than during the pre-vaccine period (P < 0.001). The absolute number of secondary bacterial infections (P < 0.01), respiratory complications (P < 0.01), and neurological complications (P < 0.001) was significantly lower during the post-vaccine period. The incidence of severe varicella was lower during the post-vaccine period than during the pre-vaccine period (P < 0.001). Conclusions: After 5.5 years of routine single-dose varicella vaccine use, we observed the impact of varicella vaccination on the incidence of varicella-related hospitalizations, especially in the target age group. However, we did not observe herd protection in the other age groups. The implementation of a second dose of the varicella vaccine in the National Immunization Program would help control disease activity.
Yazarlar (68)
1
Ener Cagri Dinleyici
2
Zafer Kurugöl
3
Ilker Devrim
4
Nuri Bayram
5
Nazan Dalgic Karabulut
6
Olcay Yasa
7
H. Tezer
8
Halil Ozdemir
9
Ergin Ciftci
10
Anil Tapisiz
11
Solmaz Çelebi
12
Mustafa Hacımustafaoğlu
13
Dilek Yilmaz
14
Nevin Hatipoglu
15
Ates Kara
16
Ozden Turel
17
Nursen Belet
18
Adem Karbuz
19
Meda Kondolot
20
Benhur Şirvan Çetin
ORCID: 0000-0002-8470-4907
21
Ömer Kılıç
22
Ozge Metin Akcan
23
Fatih Akin
24
Murat Sutcu
25
Saadet Akarsu
26
Sevtap Velipasaoglu
27
Ayper Somer
28
Metehan Ozen
29
Selim Oncel
30
Melike Emiroglu
ORCID: 0000-0003-1307-0246
31
Necdet Kuyucu
32
Enes Salı
33
Belgin Gulhan
ORCID: 0000-0003-0839-1301
34
Ayse Buyukcam
35
Aslinur Ozkaya-Parlakay
ORCID: 0000-0001-5691-2461
36
Ayse Kaman
37
Ilknur Caglar
38
Cigdem Sag
39
Cagatay Nuhoglu
40
Nihan Uygur-Kulcu
41
Selda Hancerli Torun
42
Özge Kaba
43
Gulsum Iclal Bayhan
ORCID: 0000-0002-1423-4348
44
Ozlem Ozgur Gundeslioglu
45
Canan Caymaz
46
Tuğba Erat
ORCID: 0000-0003-2434-4134
47
Gulsum Alkan
ORCID: 0000-0003-3384-769X
48
Ozlem Basoglu Oner
49
Zuhal Umit
50
Saliha Kanik-Yuksek
ORCID: 0000-0002-2538-2872
51
Ahu Kara Aksay
52
Hacer Akturk
53
Sevliya Öcal Demir
54
Meltem Polat
ORCID: 0000-0002-4608-1286
55
Deniz Çakır
ORCID: 0000-0002-7056-0615
56
Burcu Bursal
57
Talyan Celik
58
Kursat Bora Carman
59
Emine Kocabas
60
Murat Elevli
61
Denizmen Aygun
62
Rengin Siraneci
63
Emre Alhan
64
Sadık Sami Hatipoğlu
65
Gulnar Sensoy
66
Gonul Tanir
67
Erdal Ince
68
Emin Sami Arisoy
Anahtar Kelimeler
chickenpox
complication
Turkey
varicella
varicella-related hospitalization
Kurumlar
Acıbadem Mehmet Ali Aydınlar Üniversitesi
Istanbul Turkey
Akdeniz University, Faculty of Medicine
Antalya Turkey
Ankara Bilkent City Hospital
Ankara Turkey
Ankara Etlik City Hospital
Ankara Türkiye
Ankara Üniversitesi
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Başakşehir Çam ve Sakura City Hospital
Istanbul Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Çanakkale Onsekiz Mart Üniversitesi
Canakkale Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Division of Pediatric Infectious Diseases
Istanbul Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Dr. Behcet Uz Children's Hospital
Izmir Turkey
Dr. Sami Ulus Maternity and Children Research and Training Hospital
Ankara Turkey
Ege University Medical School
Izmir Turkey
Erciyes University, Faculty of Medicine
Kayseri Turkey
Eskişehir Osmangazi Üniversitesi
Eskisehir Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Haydarpasa Numune Egitim ve Arastýrma Hastanesi
Istanbul Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kanuni Sultan Suleyman Training and Research Hospital
Istanbul Turkey
Kocaeli Üniversitesi
İzmit Turkey
Koç Üniversitesi
Istanbul Turkey
Manisa City Hospital
Manisa Turkey
Marmara Üniversitesi Tip Fakültesi
Istanbul Turkey
Medeniyet University Faculty of Medicine
Istanbul Turkey
Mersin Üniversitesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Prof. Dr. Cemil Tascioglu City Hospital
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
University of Turkey Ankara
Ankara Turkey