Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
EFFECTS OF GS-441524 ON CLINICAL AND HEMATOCHEMICAL PARAMETERS OF CATS WITH EFFUSIVE FIP OVER 60 DAYS FOLLOW-UP
Assiut Veterinary Medical Journal (Egypt) · Ekim 2021
YÖKSİS Kayıtları
EFFECTS OF GS-441524 ON CLINICAL AND HEMATOCHEMICAL PARAMETERS OF CATS WITH EFFUSIVE FIP OVER
60 DAYS FOLLOW-UP
Assuit Veterinary Medical Journal · 2021 Zoological Record
PROFESÖR MEHMET MADEN →
Makale Bilgileri
DergiAssiut Veterinary Medical Journal (Egypt)
Yayın TarihiEkim 2021
Cilt / Sayfa67 · 40-51
Scopus ID2-s2.0-85150169115
Erişim🔓 Açık Erişim
Özet
Feline infectious peritonitis (FIP) is an important disease characterized by granulomatous changes in various organs including the ocular and central nervous system. FIP infection is referred as the best candidate for antiviral drug development studies due to the ineffectiveness of vaccines and being a cause of high mortality. The most important antiviral drugs developed against RNA viruses are nucleoside analogues such as GS-441524. In this study, GS-441524 was used in the treatment of three naturally infected cats with ocular lesions diagnosed with effusive FIP. The treatment of cats was planned as GS-441524 (5 mg / kg, SC, daily) administration for 12 weeks along with fluid therapy on the admission day. The treatment process included follow-ups with clinical and laboratory examinations on the admission 5th, 15th, 30th, 60th, 90th and 120th days. On the 5th day, clinical signs including ocular abnormalities and on the 30th day, laboratory findings were significantly improved in all 3 cats. While the cats were expected for monthly follow-ups, it was learned that the cats died on the 58th, 60th and 62nd days. It was concluded that GS-441524 (5 mg/kg/day, SC) has been proven to be beneficial for improving clinical, laboratory findings and animal welfare. However, it was evaluated that clinical studies involving more cases are required in order to determine the clinical efficacy of nucleoside analogues and investigate the causes of deaths occurred on the 58th, 60th and 62nd days of the treatment period with no symptoms that would grab the attention of the owners.
Yazarlar (2)
1
Erdem Gülersoy
ORCID: 0000-0001-8511-0150
2
Mehmet Maden
Anahtar Kelimeler
Coronavirus
feline infectious peritonitis
hematology
nucleoside analogues
treatment
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
2
Yazar
5
Anahtar Kelime