Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Influence of Dexamethasone on the Plasma and Milk Disposition Kinetics of Danofloxacin in Lactating Sheep
Veterinary Sciences · Mart 2025
YÖKSİS Kayıtları
Influence of Dexamethasone on the Plasma and Milk Disposition Kinetics of Danofloxacin in Lactating Sheep
Veterinary Sciences · 2025 SCI-Expanded
DOÇENT MERVE İDER →
Makale Bilgileri
DergiVeterinary Sciences
Yayın TarihiMart 2025
Cilt / Sayfa12
Scopus ID2-s2.0-105001158019
Erişim🔓 Açık Erişim
Özet
This study examines the effects of different doses of dexamethasone on the behavior of danofloxacin in the plasma and milk of lactating sheep. Understanding this interaction is crucial as both drugs are frequently used in veterinary medicine and may influence therapeutic effectiveness and milk safety. The research involved six lactating ewes, with plasma and milk samples collected at various intervals after administering low and high doses of dexamethasone alongside danofloxacin. The results revealed that although dexamethasone did not alter danofloxacin disposition in the plasma, it significantly increased its concentration in the milk, particularly at higher doses. This raises important concerns for both therapeutic efficacy and milk safety, as it indicates that milk from sheep treated with dexamethasone could contain higher danofloxacin concentrations. Overall, the findings underscore the need for careful evaluation of these medications’ combined use to ensure both optimal treatment outcomes for animals and the safety of milk products for consumers.
Yazarlar (5)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
Ramazan Yildiz
3
D. Durna Corum
4
Merve Ider
ORCID: 0000-0003-2928-5452
5
Orhan Corum
ORCID: 0000-0003-3168-2510
Anahtar Kelimeler
danofloxacin
dexamethasone
drug interactions
milk
pharmacokinetics
sheep
Kurumlar
Hatay Mustafa Kemal University Otorhinolaryngology Department
Hatay Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Burdur Mehmet Akif Ersoy
Burdur Turkey