Scopus
YÖKSİS Eşleşti
The Effectiveness of Pelvic Ultrasonography Findings in Diagnosing Precocious Puberty
Ultrasound Quarterly · Şubat 2025
YÖKSİS Kayıtları
The Effectiveness of Pelvic Ultrasonography Findings in Diagnosing Precocious Puberty
Ultrasound Quarterly · 2025 SCI-Expanded
PROFESÖR MEHMET ÖZTÜRK →
The Effectiveness of Pelvic Ultrasonography Findings in Diagnosing Precocious Puberty
Ultrasound quarterly · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ FATMA ÖZGÜÇ ÇÖMLEK →
Makale Bilgileri
DergiUltrasound Quarterly
Yayın TarihiŞubat 2025
Cilt / Sayfa41
Scopus ID2-s2.0-86000153035
Özet
Objective Gonadotropin-releasing hormone (GnRH) stimulation testing is the gold standard for distinguishing central precocious puberty (CPP) from premature thelarche (PT). Due to the limitations of this test, previous studies have elucidated the clinical and laboratory factors that predict CPP. This study explored the diagnostic importance of pelvic ultrasound in girls with CPP. Method Between May 2023 and May 2024, 55 girls with suspected CPP underwent a GnRH stimulation test and pelvic ultrasonography (PU). Additionally, bone ages were evaluated using a left wrist x-ray. Result The multivariate analysis found that basal luteinizing hormone (bLH) > 0.67 IU/L, basal follicle-stimulating hormone (FSH) > 3.5 IU/L, basal estradiol > 7.5 pg/mL, uterine volume > 2.6 cm3, and longitudinal uterine diameter >35 mm were significantly associated with a pubertal response at the GnRH test. The 2 groups had no difference in bone age and bLH/basal FSH values. Peak LH/FSH ratio had the best diagnostic performance, with an area under the curve of 0.956 (95% confidence interval, 0.864-0.993), a sensitivity of 81.82%, a specificity of 96.97%, a positive predictive value of 94.7%, and a negative predictive value of 88.9%. The optimal cutoff value was >0.59 for the LH/FSH ratio. Conclusions Uterine long axis and uterine volume measurements are noninvasive data that help distinguish CPP from PT.
Yazarlar (6)
1
Fatma Özgüç Çömlek
ORCID: 0000-0002-2752-3480
2
Mehmet Ozturk
3
Ahmet Fatih Yılmaz
ORCID: 0000-0002-1085-8882
4
M. K. Korez
ORCID: 0000-0001-9524-6115
5
Fuat Bugrul
6
Muammer Buyukinan
Anahtar Kelimeler
diagnosis
pelvis
precocious
puberty
ultrasonography
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey