Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts
Chemistry and Biodiversity · Eylül 2019
YÖKSİS Kayıtları
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
Wiley · 2019 SSCI
Arş. Gör. ESENGÜL ÖZKAYMAKOĞLU →
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of iHaplophyllum sahinii/i and iH. vulcanicum/i Extracts/title
CHEMISTRY BIODIVERSITY · 2019 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of iHaplophyllum sahinii/i and iH. vulcanicum/i Extracts/title
2019 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi İREM AYRAN ÇOLAK →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. YÜKSEL KAN →
A ProspectiveofMultipleBiopharmaceuticalActivitiesofProcyanidins-RichUapacatogoensisPaxExtracts:HPLC-ESI-TOF-MSCoupledwithBioinformaticsAnalysis
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comparative study of chemical profiling and biological effects of Doronicum orientale extracts
2022 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. EVREN YILDIZTUGAY →
Synthesis and Characterization of Copper\u2010Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. NURANİYE ERUYGUR →
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi CEYLAN DÖNMEZ →
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
2019 ISSN: 1612-1872 SSCI
Arş. Gör. ESENGÜL ÖZKAYMAKOĞLU →
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
2022 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI Q3
Prof. Dr. YÜKSEL KAN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. MEHMET TUZCU →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
2023 ISSN: 1612-1872 SCI
Prof. Dr. YÜKSEL KAN →
Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. GÖKHAN ZENGİN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Enzyme Inhibitory and Antioxidant Potential with Phytochemical Analysis of Satureja hasturkii H.Duman & Dirmenci: A New Record From Türkiye
2025 ISSN: 1612-1872 SCI-Expanded
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. ATİLLA ARSLAN →
Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. EMİNE ARSLAN →
Makale Bilgileri
ISSN16121872
Yayın TarihiEylül 2019
Cilt / Sayfa16
Scopus ID2-s2.0-85070507547
Özet
In the current study, the ethanol extracts of flower, stem, and root parts of two endemic Turkish species, e. g., Haplophyllum sahinii O. Tugay & D. Ulukuş and H. vulcanicum Boiss. & Heldr., were screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) associated with Alzheimer's disease as well as tyrosinase (TYR) linked to Parkinson's disease using ELISA microplate assay at 200 μg/mL. Among the extracts, the highest inhibition was caused by the stem extract of H. sahinii against BChE (IC50=64.93±1.38 μg/mL). Consistently, all of the extracts were found to exert a selective inhibition towards BChE to some extent. It was only the root extract of H. vulcanicum that could inhibit AChE at low level (IC50=203.18±5.33 μg/mL). None of the extracts displayed an inhibition over 50 % against TYR. Metabolite profiling of the extracts was achieved by a highly hyphenated liquid chromatographic mass spectrometric technique (HPLC-DAD-ESI-Q-TOF-MS/MS), which revealed the presence of furoquinoline (β-fagarine, γ-fagarine) and amide (tubasenicine, tubacetine) alkaloids; furano- (rutamarin), pyrano- (xanthyletine), and geranyloxy coumarins; phenylpropanoid (secoisolariciresinol), arylnaphthalene (mono-O-acetyldiphyllin apioside), and dibenzylbutyrolactone (kusunokinin, haplomyrfolin) lignans. Several important differences were observed between the extracts analyzed. β-Fagarine was the major alkaloid in H. vulcanicum, whereas γ-fagarine was present only in the roots of both Haplophyllum species; moreover, secoisolariciresinol and secoisolariciresinol dimethyl ether were the main lignans in the stems and flowers. This is the first study identifying ChE and TYR inhibitory effect and metabolic profiles of H. vulcanicum and H. sahinii.
Yazarlar (7)
1
Esengul Karahisar
2
Osman Tugay
3
Ilkay Erdogan Orhan
4
F. Sezer Senol
5
Simon Vlad Luca
6
Krystyna Skalicka-Wozniak
7
Mustafa Şahin
Anahtar Kelimeler
biological activity
cholinesterase
Haplophyllum sahinii
Haplophyllum vulcanicum
metabolite profiling
tyrosinase
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Grigore T. Popa University of Medicine and Pharmacy of Iaºi
Iasi Romania
Medical University of Lublin
Lublin Poland
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
Metrikler
9
Atıf
7
Yazar
6
Anahtar Kelime