Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Determination of Embryotoxic Dose Limit of Doxycycline and Its Effects on Some Long Bones by In Ovo Model
Journal of Veterinary Medicine Series C Anatomia Histologia Embryologia · Mart 2025
YÖKSİS Kayıtları
Determination of Embryotoxic Dose Limit of Doxycycline and Its Effects on Some Long Bones by In Ovo Model
Anatomia, Histologia, Embryologia · 2025 SCI-Expanded
Arş. Gör. REYHAN RABİA KÖK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Influence of Stomach Volume on the Liver Topography in Cats
2002 ISSN: 0340-2096 SCI 1 atıf
Prof. Dr. EMRULLAH EKEN →
Morphological Studies on Meckel s Diverticulum in Geese Anser Anser Domesticus
2002 ISSN: 0340-2096 SCI 4 atıf
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits Oryctolagus cuniculus
2007 ISSN: 0340-2096 SCI 8 atıf
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys A Stereological Approach
2013 ISSN: 03402096 SSCI
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded 1 atıf
Prof. Dr. SADULLAH BAHAR →
Investigation of Developmental Toxicity and Teratogenicity of Macrolide Antibiotics in Cultured Rat Embryos
2008 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
2013 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Human Fetal Sacral Length Measurement for the Assessment of Fetal Growth and Development by Ultrasonography and Dissection
2001 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. AHMET KAĞAN KARABULUT →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys: A Stereological Approach
2013 ISSN: 03402096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
Morphological Studies on Meckel’s Diverticulum in Geese (Anser Anser Domesticus)
2002 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
Comparative Macroanatomic Investigations of the Venous Drainage of the Heart in Akkaraman Sheep and Angora Goats
2001 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
A three-dimensional reconstructive study of pelvic cavity in the red fox (Vulpes vulpes)
2021 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits (Oryctolagus cuniculus)
2007 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right HorseKidneys A Stereological Approach
2013 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Morphometric analysis of the skull of Hamdani sheep via
Three‐Dimensional
modelling
2022 ISSN: 0340-2096 SCI-Expanded Q2
Prof. Dr. MUSTAFA ORHUN DAYAN →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured title
2013 ISSN: 03402096 SSCI
Prof. Dr. HASAN ACAR →
Calculation of cerebral hemispheres volume values (grey matter, white matter and lateral ventricle) of sheep and goat: A stereological study
2024 ISSN: 0340-2096 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN03402096
Yayın TarihiMart 2025
Cilt / Sayfa54
Scopus ID2-s2.0-105000000147
Erişim🔓 Açık Erişim
Özet
The aim of this study was to determine the embryotoxic and teratogenic effects of doxycycline on chicken embryos. Eggs placed in the incubator were checked with an ovoscope on the 7th day, and a total of 210 fertile chicken eggs were randomly divided into 7 groups. Doxycycline was applied to the experimental groups at 2500, 1250, 625, 312, and 156 μg/50 μL volumes, respectively. Group 6 was evaluated as the Negative Control Group. This group was placed in the incubator again without any treatment. Group 7 was administered 50 μL of 0.9% NaCl solution used as the solvent of the drug. The number of live and dead embryos was determined after the completion of incubation. Mortality was observed depending on the dose, and death was determined in all chicks at the highest dose (2500 μg/50 μL, p < 0.05). No macroscopic anomalies were observed. While a decrease in mortality rates was observed depending on the dose (p < 0.05), the mortality rate in the 156 μg/50 μL dose (Group 5) was similar to the Positive and Negative control groups (p > 0.05). Femur and tibia parameters could not be measured because all embryos in Group 1 (2500 μg/50 μL) died. The length and thickness of the right and left femur and tibia in Group 2 (1250 μg/50 μL) were statistically significantly (p < 0.05) lower than those of the other groups. As a result, it can be stated that doxycycline use should be avoided in pregnant mammals, especially during the development phase of organs, unless necessary.
Yazarlar (5)
1
Mustafa Sedat Arslan
ORCID: 0000-0002-4079-500X
2
Selvinaz Öztürk
ORCID: 0000-0001-8184-6849
3
Reyhan Rabia Kök
4
K. Beşoluk
5
M. O. Dayan
Anahtar Kelimeler
doxycycline
embryotoxicity
in ovo
teratogenicity
Kurumlar
İşgalaman Mah
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Q2
SJR Skoru0,317
H-Index46
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
2
Atıf
5
Yazar
4
Anahtar Kelime