Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Investigation of cardiomyopathy in children with cirrhotic and noncirrhotic portal hypertension
Journal of Pediatric Gastroenterology and Nutrition · Şubat 2015
YÖKSİS Kayıtları
Investigation of Cardiomyopathy in Children With Cirrhotic and Noncirrhotic Portal Hypertension
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION · 2015 SCI-Expanded
PROFESÖR HALİL HALDUN EMİROĞLU →
Makale Bilgileri
DergiJournal of Pediatric Gastroenterology and Nutrition
Yayın TarihiŞubat 2015
Cilt / Sayfa60 · 177-181
Scopus ID2-s2.0-84922332011
Erişim🔓 Açık Erişim
Özet
BACKGROUND:: Cirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This disorder is a well-defined entity in adults, but pediatric data are limited. The aim of the study was to determine the incidence, features, and risk factors of CCMP in children with portal hypertension (PHT). METHODS:: This study included 50 children with cirrhotic PHT (40/50) and noncirrhotic PHT (10/50). Fifty healthy children were also selected for the control group. Electrocardiography and echocardiography were used to evaluate cardiac functions. Corrected QT (QTc)≥0.45 was accepted as prolonged on electrocardiography. The study group was divided into 3 groups: cirrhotic, noncirrhotic, and control. Then, the CCMP group was created according to the diagnostic criteria. Latent CCMP was diagnosed in the presence of prolonged-QTc along with a minor criterion (tachycardia). Manifest CCMP was diagnosed in the presence of at least 2 major criteria (prolonged-QTc along with abnormal echocardiographic findings). Moreover, in this study, the risk factors for CCMP were investigated. RESULTS:: The CCMP group included 10 cases (20%). Nine of these cases had latent CCMP (18%), and the remaining one (2%) had manifest CCMP. All of the cases with CCMP had cirrhosis and ascites. None of the patients with CCMP had severe cardiac symptoms, but they were already using some cardioprotective drugs such as propanolol and spironolactone. As risk factors for CCMP, pediatric end-stage liver disease scores, Child-Pugh scores, and ascites grades were found to be significant for the determination of CCMP. The most important risk factor was ascites severity (P=0.001, odds ratio 9.4). CONCLUSIONS:: Approximately 20% of children with PHT have CCMP. A detailed cardiac examination should be carried out periodically in children with cirrhotic PHT, especially in the presence of ascites and high Child-Pugh score.
Yazarlar (10)
1
Coskun Celtik
2
Ozlem Durmaz
3
Naci Oner
4
Taner Yavuz
5
Selim Gökce
6
Aysen Aydogan
7
Kemal Nisli
8
Halil Haldun Emiroğlu
9
Rukiye E. Ömeroglu
10
Semra Sökücü
Anahtar Kelimeler
cardiac dysfunction
cardiomyopathy
children
chronic liver diseases
cirrhotic
portal hypertension
Kurumlar
Bezmi Alem University
Istanbul Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
Kocaeli Üniversitesi
İzmit Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Şifa Üniversitesi
Izmir Turkey
Metrikler
20
Atıf
10
Yazar
6
Anahtar Kelime