Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Comparative Evaluation of Cytotoxicity and Phytochemical Composition of Centaurea iconiensis (Rhaponticoides iconiensis)
Iranian Journal of Science and Technology Transaction A Science · Şubat 2021
YÖKSİS Kayıtları
Comparative Evaluation of Cytotoxicity and Phytochemical Composition of Centaurea iconiensis (Rhaponticoides iconiensis)
Iranian Journal of Science and Technology, Transactions A: Science · 2021 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Exact Solutions of Some Partial Differential Equations Using the Modified Differential Transform Method
2018 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. OZAN ÖZKAN →
Spectral Properties of Discrete Klein–Gordon s-Wave Equation with Quadratic Eigenparameter-Dependent Boundary Condition
2019 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. NİHAL YOKUŞ →
Approximation by Bivariate (p, q)-Bernstein–Kantorovich Operators
2018 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. TUNCER ACAR →
On Kantorovich Modification of (p, q)-Bernstein Operators
2018 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. TUNCER ACAR →
Artificial Bee Colony with Levy Flights for Parameter Estimation of 3-p Weibull Distribution
2020 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. NİMET YAPICI PEHLİVAN →
Comparative Evaluation of Cytotoxicity and Phytochemical Composition of Centaurea iconiensis (Rhaponticoides iconiensis)
2020 ISSN: 1028-6276 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Comparative Evaluation of Cytotoxicity and Phytochemical Composition of Centaurea iconiensis (Rhaponticoides iconiensis)
2021 ISSN: 1028-6276 SCI-Expanded Q3
Prof. Dr. OSMAN TUGAY →
A New Flexible Discrete Distribution with Application to Zero-Inflated Regression Analysis
2022 ISSN: 1028-6276 SCI-Expanded Q3
Doç. Dr. YUNUS AKDOĞAN →
Makale Bilgileri
ISSN10286276
Yayın TarihiŞubat 2021
Cilt / Sayfa45 · 65-75
Scopus ID2-s2.0-85096401689
Özet
Cancer is a disorder that results in abnormal and irregular proliferation of cells in the organ or tissue of the body. In Turkey flora, there are many medicinal plants that have great therapeutic importance. Rhaponticoides iconiensis is endemic to Turkey. In the present study, the methanol extracts and sub-extracts of leafy stem and flowers of R. iconiensis were evaluated for cytotoxic activity against Colo 205, A549, HepG2, MCF7 and Beas-2b cell lines by MTT method. The compounds of R. iconiensis extracts were characterized and quantitated by LC–MS/MS. As a result, methanol extracts were not cytotoxic against A549, but were cytotoxic to the Colo 205, HepG2, MCF-7 and Beas-2b cell lines. Among the sub-extracts, dichloromethane, ethyl acetate and n-hexane sub-extracts of flowers and dichloromethane sub-extract of the stem were most cytotoxic against A549, HepG2, MCF-7 and Colo 205 cell lines, respectively. As sub-extracts were most effective against MCF-7 cancer cell line, it can be said that extracts might be effective in estrogen-sensitive cancer cells such as breast and cervix. The cytotoxic effects of sub-extracts can be explained by the variances of compounds and synergistic effects of different secondary metabolites.
Yazarlar (4)
1
Osman Tugay
2
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
3
Eren Demirpolat
4
Mustafa Şahin
Anahtar Kelimeler
Asteraceae
Colo205
Cytotoxicity
HepG2
LC–MS/MS
MCF-7
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Iranian Journal of Science and Technology, Transaction A: Science
Q2
SJR Skoru0,287
H-Index36
YayıncıSpringer International Publishing AG
ÜlkeSwitzerland
Agricultural and Biological Sciences (miscellaneous) (Q2)
Chemistry (miscellaneous) (Q3)
Earth and Planetary Sciences (miscellaneous) (Q3)
Engineering (miscellaneous) (Q3)
Mathematics (miscellaneous) (Q3)
Physics and Astronomy (miscellaneous) (Q3)
Metrikler
8
Atıf
4
Yazar
6
Anahtar Kelime