Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Macrolide allergy in children and the negative predictive value of drug provocation tests in mild index reactions
Asthma Allergy Immunology · Ocak 2021
YÖKSİS Kayıtları
Macrolide Allergy in Children and the Negative Predictive Value of Drug Provocation Tests in Mild Index Reactions
Asthma Allergy Immunology · 2021 TR DİZİN
Doç. Dr. İLKNUR KÜLHAŞ ÇELİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Retrospective Evaluation of 1054 Patients with Primary Immunodeficiency
2008 ISSN: 1308-9234 Emerging Sources Citation Index
Öğr. Gör. REYHAN KARA →
The Known Genetic Defects in Common Variable Immunodeficiency
2014 ISSN: 1308-9234 Emerging Sources Citation Index
Öğr. Gör. REYHAN KARA →
Alternaria and Cladosporium spores in the atmosphere of Konya and their relationship with meteorological factors
2014 ISSN: 1308-9234 TR DİZİN
Doç. Dr. HÜLYA ÖZDEMİR →
Serum Periostin Level and Exhaled Nitric Oxide in Children with Asthma
2018 ISSN: 13089234 TR DİZİN
Prof. Dr. ALİ ÜNLÜ →
Primer İmmün Yetmezlikli 1054 Olgunun Retrospektif Değerlendirilmesi
2008 ISSN: 1308-9234 Endekste taranmıyor
Prof. Dr. ALAADDİN YORULMAZ →
Topikal Glukokortikoid Kullanımına Bağlı Cushing Sendromu
2017 ISSN: 1308-9234 ESCI
Doç. Dr. MUAMMER BÜYÜKİNAN →
An Indolent Cause of Recurrent Anaphylaxis with NSAIDs: Systemic Mastocytosis
2019 ISSN: 1308-9234 Emerging Sources Citation Index (ESCI)
Doç. Dr. ERAY YILDIZ →
Reverse Angle: Immunological Evaluation of Patients with Idiopathic Thrombocytopenic Purpura: A Retrospective Cohort Study
2019 ISSN: 1308-9234 Emerging Sources Citation Index (ESCI)
Doç. Dr. ERAY YILDIZ →
The Effect of Allergen Immunotherapy on Serum Periostin Levels in Children with Allergic Rhinitis
2019 ISSN: 1308-9234 ESCI
Dr. Öğr. Üyesi NERİMAN AKDAM →
Reverse Angle: Immunological Evaluation of Patients with Bronchiectasis
2020 ISSN: 1308-9234 Emerging Sources Citation Index (ESCI)
Doç. Dr. ERAY YILDIZ →
Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency
2020 ISSN: 1308-9234 Emerging Sources Citation Index (ESCI)
Doç. Dr. ERAY YILDIZ →
Bone Metabolism Alterations in Patients with Common Variable Immune Deficiency: A Retrospective Cohort Study
2020 ISSN: 1308-9234 Emerging Sources Citation Index (ESCI)
Doç. Dr. ERAY YILDIZ →
Internet Use Habits of Parents with Children Suffering from Food Allergy
2019 ISSN: 1308-9234 TR DİZİN
Doç. Dr. İLKNUR KÜLHAŞ ÇELİK →
Macrolide Allergy in Children and the Negative Predictive Value of Drug Provocation Tests in Mild Index Reactions
2021 ISSN: 1308-9234 TR DİZİN
Doç. Dr. İLKNUR KÜLHAŞ ÇELİK →
The Impact of SARS-CoV-2 Transmission Fear and the COVID-19 Pandemic on the Mental Health of Patients with Primary Immunodeficiency Disorders and Severe Asthma, and Other High-Risk Groups
2021 ISSN: 1308-9234 TR DİZİN
Doç. Dr. ERAY YILDIZ →
The Relationship Between Body-Mass Index,
Central Obesity and Asthma in Children
2021 ISSN: 1308-9234 ESCI
Doç. Dr. HÜLYA ÖZDEMİR →
Incidence of Micronucleus in Primary Immunodeficiency Diseases: Detection by Micronucleus and FISH Techniques
2009 ISSN: 1308-9234 TR DİZİN
Prof. Dr. HASAN ACAR →
Atopy and allergic diseases in immunoglobulin A deficiency
2012 ISSN: 1308-9234 E-SCI, EBSCO, TR DİZİN Q4
Prof. Dr. HASİBE ARTAÇ →
Clinical features and risk factors in children with acute asthma attack
2012 ISSN: 1308-9234 TR DİZİN
Prof. Dr. HASİBE ARTAÇ →
The demographic datas of chronic granulomatous disease patients and the comparation of the clinical datas before and after interferon-gamma treatment in our country
2013 ISSN: 1308-9234 TR DİZİN
Prof. Dr. HASİBE ARTAÇ →
Makale Bilgileri
ISSN13089234
Yayın TarihiOcak 2021
Cilt / Sayfa19 · 92-99
Scopus ID2-s2.0-85153851560
Erişim🔓 Açık Erişim
Özet
Objective: Macrolide allergy is rarely reported, and there is limited knowledge of hypersensitivity reactions (HRs) in children. The negative predictive value (NPV) of drug provocation tests (DPTs) for macrolides is unresolved. We aim to evaluate the clinical features of macrolide allergy in children, and determine the NPV of macrolide DPTs. Materials and Methods: Pediatric patients who were referred to our allergy department with a suspicion of macrolide allergy were evaluated by DPTs with or without prior skin tests between 2011 and 2020. Characteristics of the HRs and patients, the results of skin and DPTs were recorded. At least three months after evaluation of the patients with allergy work up, telephone interviews were performed. Patients were asked whether they had reused the suspected macrolide or not. Patients who reported HR during subsequent drug intake were invited for reevaluation. Results: A total of 160 children (161 reactions) (55.6% male) with a suspicion of macrolide allergy were enrolled for the study, and all children had a mild index reaction. The median age was 48 (18-102) months, and the median time between the suspected allergic reaction and allergy work-up was 3 (2-8) months. The most frequently reported suspected agent was clarithromycin, in 151 patients (94.4%). Macrolide allergy was confirmed in 8 (5%) patients. Only one patient reported skin eruptions upon reuse despite a negative DPT and he was invited to be reevaluated. A second DPT was performed resulting in urticarial lesions. The NPV was found to be 97.4% for negative DPT with macrolides. Conclusion: Confirmed macrolide allergy is rare in children, and DPTs are the gold standard to assess suspected macrolide allergy. The NPV of macrolide provocation tests seems to be high in children.
Yazarlar (7)
1
Betül Karaatmaca
ORCID: 0000-0002-8383-6350
2
Şule Büyük Yaytokgil
ORCID: 0000-0002-9393-7497
3
Ilknur Kulhas Celik
ORCID: 0000-0003-3812-9654
4
Özge Yilmaz Topal
ORCID: 0000-0001-5245-2488
5
Ersoy Civelek
ORCID: 0000-0002-1780-4801
6
Muge Toyran
ORCID: 0000-0002-2490-0551
7
Emine Dibek Misirlioglu
ORCID: 0000-0002-3241-2005
Anahtar Kelimeler
Children
Drug hypersensitivity
Drug provocation test
Macrolide
Negative predictive value
Kurumlar
Ankara City Hospital
Ankara Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Asthma Allergy Immunology
Q4
SJR Skoru0,170
H-Index6
ÜlkeTurkey
Immunology (Q4)
Immunology and Allergy (Q4)
Pulmonary and Respiratory Medicine (Q4)
Metrikler
1
Atıf
7
Yazar
5
Anahtar Kelime